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Fluorine-doped iron oxide nanoparticle contrast agent and preparation method thereof

An iron oxide nanoparticle and contrast agent technology, which is applied in the fields of nuclear magnetic resonance/magnetic resonance imaging contrast agent, nanomedicine, nanotechnology, etc. Weak magnetic resonance imaging ability and other problems, to achieve the effect of strong T2 magnetic resonance imaging performance, improved relaxation performance, and strong hydrogen bonding

Active Publication Date: 2021-04-16
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The nanoparticle contrast agent of the present invention solves the low sensitivity of the existing iron oxide nanoparticles, such as the r2 relaxation rate of Feridex is only 120mM-1s-1, its own T2 magnetic resonance imaging ability is weak, and its low sensitivity makes it difficult to detect the presence of the human body itself Some areas of low signal intensity are distinguished from the lesion site, reducing the technical problem of the accuracy of detection of this area and its surroundings

Method used

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  • Fluorine-doped iron oxide nanoparticle contrast agent and preparation method thereof
  • Fluorine-doped iron oxide nanoparticle contrast agent and preparation method thereof
  • Fluorine-doped iron oxide nanoparticle contrast agent and preparation method thereof

Examples

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Effect test

Embodiment 1

[0039] Example 1: Controlled synthesis of cubic structure fluorine-doped iron oxide nanoparticle aggregate magnetic resonance imaging contrast agent with a side length of 60 nm

[0040] A method for preparing a magnetic resonance imaging contrast agent of a fluorine-doped cubic iron oxide nanoparticle aggregate with a side length of 60 nm, comprising the following steps:

[0041] Measure 10 mL of octadecene solution into a 50 mL three-necked flask, and disperse 2 mL of oleic acid and 63 mg of sodium fluoride in the octadecene solution. High-purity nitrogen was passed into the above-mentioned three-necked flask as a protective gas during the reaction, and heated to 120° C. to remove low-boiling impurities and moisture in the reaction solvent. After incubating at 120°C for 30 minutes, add 0.2mL iron carbonyl, then raise the temperature of the solution to 310°C at a heating rate of 10°C / min and keep it there for a period of time until the color of the solution turns dark gray, an...

Embodiment 2

[0043] Example 2: Controlled synthesis of a cubic structure fluorine-doped iron oxide nanoparticle aggregate magnetic resonance imaging contrast agent with a side length of 90 nm

[0044] A method for preparing a magnetic resonance imaging contrast agent with a cubic structure of fluorine-doped iron oxide nanoparticles with a side length of 90 nm, comprising the following steps:

[0045] Measure 10 mL of octadecene solution into a 50 mL three-necked flask, and dissolve 2.5 mL of oleic acid and 63 mg of sodium fluoride in the octadecene solution. High-purity nitrogen was passed into the above-mentioned three-necked flask as a protective gas during the reaction, and heated to 120° C. to remove low-boiling impurities and moisture in the reaction solvent. After incubating at 120°C for 30 minutes, add 0.2mL iron carbonyl, then raise the temperature of the solution to 310°C at a heating rate of 10°C / min and keep it there for a period of time until the color of the solution turns dar...

Embodiment 3

[0048] Example 3: Controlled synthesis of cubic structure fluorine-doped iron oxide nanoparticle aggregate magnetic resonance imaging contrast agent with a side length of 120 nm

[0049] A method for preparing a magnetic resonance imaging contrast agent with a cubic structure of fluorine-doped iron oxide nanoparticles with a side length of 120 nm, comprising the following steps:

[0050] Measure 10 mL of octadecene solution into a 50 mL three-necked flask, and dissolve 3 mL of oleic acid and 63 mg of sodium fluoride in the octadecene solution. High-purity nitrogen was passed into the above-mentioned three-necked flask as a protective gas during the reaction, and heated to 120° C. to remove low-boiling impurities and moisture in the reaction solvent. After incubating at 120°C for 30 minutes, add 0.2mL iron carbonyl, then raise the temperature of the solution to 310°C at a heating rate of 10°C / min and keep it there for a period of time until the color of the solution turns dark ...

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Abstract

The invention discloses a fluorine-doped iron oxide nanoparticle contrast agent and a preparation method thereof, wherein the nanoparticles form a magnetic aggregate with a cubic structure, and the magnetic aggregate is prepared by reacting an iron precursor such as carbonyl iron or ferric oleate with sodium fluoride in the presence of oleic acid and octadecene. Compared with a traditional spherical iron oxide nanoparticle contrast agent, the contrast agent has larger effective radius and local magnetic field non-uniformity, the transverse relaxation rate r2 is obviously higher than that of conventional spherical nanoparticles and T2 magnetic resonance imaging performance is very high, so that the more accurate and reliable basis can be provided for clinical research and disease diagnosis of magnetic resonance imaging.

Description

technical field [0001] The invention belongs to the field of diagnostic reagents, and in particular relates to a cubic structure fluorine-doped iron oxide nanoparticle aggregate magnetic resonance imaging contrast agent and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (MRI) has the characteristics of good tissue penetration, no radiation damage and high spatial resolution, and has important applications in the diagnosis of malignant tumors and other diseases. Since the signal source of MRI is hydrogen protons in water molecules, its magnetic response signal is weak and the specificity of distribution in the human body is poor, resulting in generally low signal intensity, which affects the imaging quality. In order to enhance the contrast of MRI, it is often necessary to use contrast agents to change the relaxation rate of hydrogen protons to improve the imaging contrast. Superparamagnetic iron oxide nanoparticles are FDA-approved cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08A61K49/18B82Y5/00B82Y15/00
Inventor 周春宇孙涛刘一丁龚明福张冬张亮刘云徐中胜杜梦梦康迅
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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