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Protein structure prediction method and device, platform and storage medium

A protein structure and prediction method technology, applied in the field of protein structure prediction, can solve problems such as affecting the integrity and accuracy of the target protein structure, low similarity, and the target sequence cannot completely find the template sequence.

Pending Publication Date: 2021-03-19
康码芯(上海)智能科技有限公司
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  • Claims
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Problems solved by technology

During the homology modeling process, it may happen that the target sequence cannot completely find the template sequence, that is, the similarity between the two is low, which affects the integrity and accuracy of the target protein structure prediction

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  • Protein structure prediction method and device, platform and storage medium
  • Protein structure prediction method and device, platform and storage medium
  • Protein structure prediction method and device, platform and storage medium

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Embodiment Construction

[0055] In the following description, specific details such as specific system structures and technologies are presented for the purpose of illustration rather than limitation, so as to thoroughly understand the embodiments of the present application. However, it will be apparent to those skilled in the art that the present application may be practiced in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.

[0056] It should be understood that when used in this specification and the appended claims, the term "comprising" indicates the presence of described features, integers, steps, operations, elements and / or components, but does not exclude one or more other Presence or addition of characteristics, wholes, steps, operations, elements, components and / or collections.

[0057] In order ...

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Abstract

The invention discloses a protein structure prediction method. The method comprises the following steps: extracting a target sequence from a to-be-detected protein file; matching the target sequence in a protein database with a known structure to find a matching sequence; obtaining a matching structure of the matching sequence according to the matching sequence; constructing an initial three-dimensional structure model of the target sequence based on the matching sequence and the matching structure thereof; combining the unmatched sequence segment of the target sequence with one part of the adjacent matched sequence segment to form a sub-target sequence; searching a matching subsequence and a structure of the matching subsequence of the sub-target sequence in a protein database with a known structure; and filling the missing part in the initial three-dimensional structure model according to the searched matching subsequence and the structure thereof to obtain the three-dimensional structure of the to-be-detected protein file. By adopting the protein structure prediction method provided by the invention, the structure of the protein can be more accurately predicted.

Description

technical field [0001] The invention relates to the field of protein structure prediction, in particular to a protein structure prediction method, device, platform and storage medium. Background technique [0002] The study of the three-dimensional structure of proteins can explain protein functions at the molecular level. For example, protein complexes are often at the heart of many cellular metabolic processes. Describing the mutual contact and quaternary structure of each component in a protein complex from the molecular level will help researchers understand the mechanism of protein complex operation in its metabolic environment and gain inspiration for regulating this operation process. In recent years, protein complexes in the Protein Crystal Data Bank (PDB) have also grown rapidly due to the continuous development of electron microscopy-based structure determination methods. However, the speed of experimental methods to determine the three-dimensional structure of p...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B15/00G16B30/10G16B45/00
CPCG16B15/00G16B30/10G16B45/00
Inventor 郭敏余晴林介一于雪
Owner 康码芯(上海)智能科技有限公司
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