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Traditional Chinese medicine composition for treating depression

A composition and technology for depression, applied in the field of medicine, to achieve high safety, improve the quality of life, and improve the effect of TCM symptoms

Active Publication Date: 2021-03-02
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current antidepressant traditional Chinese medicine still lacks drugs that can improve sleep and regulate the spleen and stomach as antidepressant targets.

Method used

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  • Traditional Chinese medicine composition for treating depression
  • Traditional Chinese medicine composition for treating depression
  • Traditional Chinese medicine composition for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The granule dosage form of embodiment 1 Chinese medicine composition of the present invention

[0024] Using the conventional method of preparing granules, take 6 parts of Bupleurum bupleuri, 6 parts of Hypericum perforatum, 5 parts of white peony, 5 parts of curcuma, 5 parts of bergamot, 6 parts of heterophylla, 5 parts of Atractylodes macrocephala, 4 parts of Fushen, and 5 parts of jujube seed. 5 parts of valerian, 6 parts of Albizia juniper, and 3 parts of licorice, soaked in water for 0.5 hours and then extracted twice, the amount of water added was 10 times and 8 times respectively, the first extraction was 2 hours, the second extraction was 1.5 hours, filtered , combining the filtrates, concentrating, drying and crushing, adding an appropriate amount of auxiliary materials, mixing, granulating, sieving and drying to obtain a pharmaceutical composition preparation in the form of granules.

Embodiment 2

[0025] Tablet dosage form of embodiment 2 pharmaceutical composition of the present invention

[0026] Using the conventional method of preparing tablets, take 0.5 parts of Bupleurum, 0.5 parts of Hypericum perforatum, 1 part of Radix Paeoniae Alba, 0.8 parts of Curcuma, 0.8 parts of Bergamot, 1 part of Radix Pseudostellariae, 1 part of Atractylodes Rhizome, 0.5 parts of Fushen, Zizao Ren 0.8 parts, 1 part of valerian root, 1 part of Albizia Julibrissin, 0.5 part of licorice, soaked in 70% ethanol for 0.5 hours and then extracted twice, the amount of water added was 6 times and 4 times respectively, the first extraction was 2 hours, the second extraction After 1 hour, filter, combine the filtrates, concentrate, dry and pulverize, add appropriate amount of excipients, mix well, granulate, sieve, dry, and the obtained granules are further compressed into tablets and dried to obtain a drug combination in the form of tablets pharmaceutical preparations.

Embodiment 3

[0027] The capsule dosage form of embodiment 3 pharmaceutical compositions of the present invention

[0028] Using the conventional method of preparing capsules, take 1 part of Bupleurum, 1 part of Hypericum perforatum, 2 parts of Paeoniae Alba, 2 parts of Curcuma, and 1.5 parts of Bergamot, add 60% ethanol to soak for 0.5 hours and then extract twice, adding water respectively 7 times, 5 times, extract for 2 hours for the first time, extract for 1 hour for the second time, filter, combine the filtrate, concentrate, dry, crush, add appropriate amount of excipients, mix, granulate, sieve, dry, and the prepared The granules are packed into capsule shells to make capsules, that is, the pharmaceutical composition preparation in the form of capsules is obtained.

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Abstract

The invention discloses a compound traditional Chinese medicine for treating depression. Radix bupleuri, radix curcumae, fingered citron, radix paeoniae alba, hypericum perforatum and the like serve as raw materials and are extracted and separated through 0-70% ethyl alcohol to be made into a certain dosage form. The medicines are combined to soothe the liver, rectify qi, invigorate the spleen, nourish the heart, soothe the the nerves and relieve depression, and are used for treating mild and moderate depression caused by liver depression, spleen deficiency and mental retardation. Pharmacodynamic and clinical curative effect research results show that the compound traditional Chinese medicine is an effective medicine for treating depression and promoting sleep.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for treating depression. Background technique [0002] Depression is a common emotional and mental disorder. With the acceleration of the pace of social life, depression has become a high incidence disease in today's society. According to the statistics of the World Health Organization, the prevalence of various depressions accounts for about 11% of the global population, and the risk of large-scale outbreaks of depression is 15% to 20%. Many patients with major depressive disorder committed suicide due to lack of regular treatment in time, and it is predicted that depression will become the second largest disease threatening human health in 2020. [0003] At present, Western medicine mainly uses monoamine oxidase inhibitors, tricyclic antidepressants, tetracyclic antidepressants, 5-HT reuptake inhibitors, and 5-HT-NE reupt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/20A61P25/24
CPCA61K36/233A61K36/38A61K36/71A61K36/65A61K36/9066A61K36/752A61K36/36A61K36/284A61K36/076A61K36/725A61K36/84A61K36/48A61K36/484A61P25/24A61P25/20A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 王宇红韩远山韩炯
Owner HUNAN UNIV OF CHINESE MEDICINE
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