Methods of managing eosinophilic esophagitis

Abstract

Described herein are methods of managing eosinophilic esophagitis (EoE) in a patient, wherein the patient records the number of episodes of dysphagia on a patient report outcome (PRO) questionnaire prior to and during the course of treatment. While on treatment, the number of episodes of dysphagia are reduced, as reported on the PRO questionnaire. In some embodiments, the esophageal eosinophils are counted before or after treatment, or both. In some embodiments, esophageal eosinophils counts are not correlated with a reduction in the episodes of dysphagia.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application 62 / 633,432, filed February 21, 2018, which is hereby incorporated by reference in its entirety for all purposes. [0003] technical background [0004] Dysphagia (such as difficulty or pain that occurs when swallowing) is associated with a number of diseases or conditions, including achalasia, diffuse spasticity, esophageal strictures (such as those caused by scar tissue or inflammation), esophageal tumors, esophageal rings, GERD , scleroderma and inflammatory disorders. [0005] Esophageal inflammation, such as eosinophilic esophagitis (EoE), a disease characterized by high levels of eosinophils in the esophagus and basal zonal hyperplasia, is increasingly being diagnosed in both children and adults . Many aspects of the disease remain unclear, including its etiology, natural history, and optimal treatment. EoE affects all ages, but most commonly occ...

AI Technical Summary

Problems solved by technology

However, another distinguishing feature is dysphagia, as elevated levels of eosinophils can lead to fibrosis of the esophagus, leading to loss of esophageal function and dysphagia

Images