Application of Pien Tze Huang and its preparations in the preparation of drugs for the prevention and treatment of enterovirus ev71 infection

Abstract

The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of Pien Tze Huang and its preparations in the preparation of anti-enterovirus EV71 infection drugs. The invention discloses the application of Pien Tze Huang in the preparation of anti-enterovirus EV71 infection drugs, and the antiviral activity research has been carried out on the application, which shows that during the infection process of enterovirus EV71, Pien Tze Huang can significantly inhibit cell pathology, inhibit virus replication, It reduces the load of virus particles and has strong anti-EV71 virus activity, which provides a scientific basis for the new use of Pien Tze Huang.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to the application of Pien Tze Huang and its preparation in preparing medicines for preventing and treating enterovirus EV71 infection. Background technique [0002] Enterovirus 71 (EV71) is a neurotropic virus belonging to the genus Enterovirus of the family Picornaviridae. It is one of the main pathogens causing hand, foot and mouth disease, angina or rash in children, especially hand, foot and mouth disease. , Among the HFMD cases with laboratory etiological diagnosis results, the EV71 positive rate accounted for about 44%, the EV71 positive rate accounted for 74% of the severe cases, and the death cases accounted for 93%. EV71 infection seriously affects people's daily life and life and health, and has become an important global public health problem, which has attracted extensive attention and research from various health institutions and research institut...

AI Technical Summary

Problems solved by technology

Although drugs have been used to treat EV71 HFMD clinically, they have not been standardized and widely used, and there are still some deficiencies: 1) most clinical trials of drugs are tested in a small range, lacking evidence-based basis; 2) for the treatment of There are far more drugs in EV71 infection models (cells and animals) than in clinical trials; 3) Differences between animal infection models and clinical human infections increase the uncertainty of drugs in the clinical research phase; 4) EV71 The high mortality rate of children with severe hand, foot and mouth disease is mainly due to severe complications such as neurogenic pulmonary edema, aseptic meningitis, and encephalitis. However, the mechanism has not been clarified, which limits the development of anti-EV71 drugs

[0005] At present, there is no therapeutic drug for EV71 infection. Due to the time-consuming, high cost and high risk of new drug development, screening of anti-EV71 infection drugs from marketed drugs provides ideas for symptomatic treatment and new drug development of EV71 infection diseases

Pien Tze Huang is a heat-clearing and detoxifying Chinese patent medicine that has been used for nearly 500 years. Preliminary pharmacological effects and clinical studies have shown that Pien Tze Huang has significant anti-inflammatory, antipyretic, immune regulation, and tumor treatment effects. There is no report that Pien Tze Huang is effective in treating EV71 infection. The application of drugs such as hand, foot and mouth disease, angina or rash

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