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Application of Lactobacillus reuteri live bacteria in preparing medicine for treating or alleviating symptoms of non-alcoholic fatty liver disease

A Lactobacillus reuteri, non-alcoholic technology, applied in the field of biomedicine, can solve the problem of few preventive and therapeutic drugs, and achieve the effect of improving liver function damage and alleviating symptoms

Active Publication Date: 2021-12-31
湖州金诺康健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, about 15% of adults in Shanghai, Guangzhou and other developed areas of China have non-alcoholic fatty liver; however, in addition to increasing exercise and low-fat diet, there are still few effective preventive and therapeutic drugs

Method used

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  • Application of Lactobacillus reuteri live bacteria in preparing medicine for treating or alleviating symptoms of non-alcoholic fatty liver disease
  • Application of Lactobacillus reuteri live bacteria in preparing medicine for treating or alleviating symptoms of non-alcoholic fatty liver disease
  • Application of Lactobacillus reuteri live bacteria in preparing medicine for treating or alleviating symptoms of non-alcoholic fatty liver disease

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Embodiment 1

[0031] 1. Experimental design

[0032] (1) Establishment of mouse obesity model induced by high-fat diet

[0033] Thirty-six healthy male C57BL / 6 mice aged 4 weeks and with similar body weight were selected as the experimental subjects, and were randomly divided into 3 groups: Group ① was fed with basal diet as the negative control group for modeling; Groups ② and ③ were fed with high-fat diet Feed, carry out the construction of non-alcoholic fatty liver model of 8-week high-fat diet. After the model was built, one cage was taken from each group for model evaluation.

[0034] (2) Lactobacillus reuteri colonization test

[0035] Lactobacillus reuteri LR is isolated from the feces of healthy people. The strain name is Lactobacillus reuteri (Lactobacillus reuteri) DSM 17938. It is a widely used commercial probiotic. List of Strains from , a genetic resource available to the public.

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Abstract

The present invention discloses the new application of Lactobacillus reuteri live bacteria in the preparation of medicines for treating or alleviating non-alcoholic fatty liver symptoms, medicines for improving liver function damage and medicines for anti-inflammation through animal experiments. The application of Bacillus provides a new direction.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Lactobacillus reuteri live bacteria in the preparation of medicines for treating or alleviating the symptoms of non-alcoholic fatty liver. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) refers to a pathological syndrome characterized by diffuse hepatic fatty lesions caused by excluding alcohol and other definite liver damage factors, including simple fatty liver and its evolution Steatohepatitis (NASH) and cirrhosis. Nonalcoholic fatty liver is a high risk factor for hyperlipidemia, type 2 diabetes, atherosclerosis, heart failure, myocardial infarction, and stroke. [0003] In recent years, fatty liver has become an important public health problem worldwide. In my country, non-alcoholic fatty liver disease (NASH) has surpassed chronic viral hepatitis to become the leading liver disease. In Western countries, approximately 20%-30% ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/747A61P1/16A61P29/00
CPCA61K35/747A61P1/16A61P29/00A61K2035/115
Inventor 蒋增良候国新潘元根
Owner 湖州金诺康健康科技有限公司
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