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Nanometer emulsion composition with effect of improving skin barrier and application of nanometer emulsion composition

A nanoemulsion and skin-improving technology, which is applied in skin care preparations, medical preparations containing active ingredients, and cosmetic preparations, etc. It can solve the adverse effects of the environment and bioaccumulation, increase the irritation of the formula, and be difficult to degrade, etc. problems, to achieve the effect of improving utilization rate and product efficacy, increasing transdermal absorption, and reducing irritation

Active Publication Date: 2020-08-25
HUAANTANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Various emulsified compositions have been widely used in the field of cosmetics or pharmaceuticals, but most of their emulsified compositions are creamy or cloudy emulsions with high viscosity ;In order to improve the appearance and reduce the viscosity, some cosmetics achieve the milky white appearance of the material body by adding traditional sunscreens (such as styrene / acrylic acid (ester) copolymers), but these substances belong to plastic particles, are not easy to degrade, and are harmful to the environment and bioaccumulation It has adverse effects, and does not have the moisturizing and moisturizing effects of emulsified formulas; other methods that can reduce the emulsified particle size, the commonly used methods are D-phase emulsification, coagulation method or PIT emulsification, which has a great influence on the emulsifier selection of the formula , the amount of emulsifier, the type and content of oil, and the process have certain requirements; the increase in emulsifier content may lead to an increase in the irritation of the formula; and due to stability reasons, the oil content cannot be too high, resulting in insufficient moisture; oil The types are limited and cannot meet the skin feeling requirements required for emulsified formulations; these characteristics limit its application in cosmetics or pharmaceuticals for skin, scalp and hair, etc.

Method used

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  • Nanometer emulsion composition with effect of improving skin barrier and application of nanometer emulsion composition
  • Nanometer emulsion composition with effect of improving skin barrier and application of nanometer emulsion composition
  • Nanometer emulsion composition with effect of improving skin barrier and application of nanometer emulsion composition

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Effect test

Embodiment 1-33 and comparative example 1-12

[0065] Heat component (A) emulsifier, component (B) higher alcohol and component (C) grease to the specified temperature according to the ratio and stir to dissolve evenly, which is the oil phase premix; water and component (D) polyol Or heat the polysaccharide to the specified temperature and stir and dissolve evenly, which is the water phase premix; add the oil phase premix to the water phase premix, keep warm and stir evenly, and carry out high-pressure homogenization until the average particle size of the material body is ≤200nm (particle size comparison example Homogenize to about 250nm and 350nm); cool down, add the remaining components, adjust the pH to the specified range, and obtain the nanoemulsion composition. The specific data of performance indicators such as the appearance, average particle size, viscosity, use feeling, moisturizing performance, elastic effect and smooth effect of the prepared nanoemulsion composition are shown in Tables 1-6.

[0066] Table 1 com...

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Abstract

The invention discloses a nanometer emulsion composition with an effect of improving the skin barrier and application of the nanometer emulsion composition. The nanometer emulsion composition comprises the following ingredients (A) 0.005 to 2.5 percent of an emulsifier, (B) 0.01 to 5 percent of higher alcohol, (C) 0.02 to 60 percent of grease, and (D) 3 to 30 percent of polyhydric alcohol or polysaccharide, wherein the content of the ingredient (C) is greater than or equal to the sum of the contents of the ingredient (A) and the ingredient (B). By selecting the low-content and specific-kind emulsifier to be compounded with the specific contents of the higher alcohol, the grease and the polyhydric alcohol or the polysaccharide and controlling the content of the grease to be greater than thesum of the weight of the emulsifier and the compounding weight of the emulsifier, the nanometer emulsion composition with the average particle diameter being smaller than or equal to 200 nm is prepared. The nanometer emulsion composition has low viscosity, so that a convenient use feeling is realized; the influence by different kinds of grease is avoided; the stability is high; a good transparenteffect and soft and moist skin feelings like cream are realized; the skin moisture preserving degree, the moisturizing degree, the smoothness degree and the softness can be improved; and the consumption of the emulsifier is reduced, so that the skin tolerance can be increased.

Description

technical field [0001] The invention relates to the technical field of cosmetics or medicines, in particular to a nanoemulsion composition with improved skin barrier and its application. Background technique [0002] Various emulsified compositions have been widely used in the field of cosmetics or pharmaceuticals, but most of their emulsified compositions are cream-like or cloudy emulsions with high viscosity; in order to improve appearance and reduce viscosity, some cosmetics add traditional opacifiers (such as styrene / acrylic acid (ester) copolymer) achieves a milky white appearance, but these substances belong to plastic particles, are not easy to degrade, have adverse effects on the environment and bioaccumulation, and do not have the moisturizing and moisturizing effects of emulsified formulas; There are other methods to reduce the emulsified particle size. The commonly used methods are D-phase emulsification, coagulation method or PIT emulsification, which have certai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/06A61K8/31A61K8/34A61K8/365A61K8/44A61K8/55A61K8/60A61K8/86A61K8/81A61K8/37A61K8/92A61K8/891A61Q19/00
CPCA61K8/068A61K8/604A61K8/86A61K8/442A61K8/553A61K8/342A61K8/31A61K8/345A61K8/34A61K8/365A61K8/8147A61K8/375A61K8/922A61K8/891A61Q19/00A61K2800/5922
Inventor 何健容宝珊许显何廷刚冯有好刘思欣徐碧茜张兴宏余育玲李艳媚郑晓旻罗竺荔魏云传艾勇邱孟德任璐耿林
Owner HUAANTANG BIOTECH GRP CO LTD
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