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Application of ligustilide in elimination of quinolone drug residues in cultured fishes

A technology of artebenolide and quinolones, which is applied in the field of aquatic animal pharmacology, can solve problems such as quinolone drug residues, aquatic product quality and safety issues, and impact on consumers' health, so as to shorten the residual time, reduce risks, and guarantee The effect of quality and safety

Active Publication Date: 2020-08-11
YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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Problems solved by technology

With the rapid development of my country's aquaculture industry, the output of my country's aquatic products ranks first in the world, but also with the frequent occurrence of bacterial diseases in various aquatic animals, quinolones are used in large quantities. On the one hand, the bacterial diseases of aquatic animals have been eliminated. Treatment, on the other hand, also caused the problem of quinolone drug residues in aquatic products, caused the quality and safety of aquatic products, and then affected the health of consumers

Method used

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  • Application of ligustilide in elimination of quinolone drug residues in cultured fishes
  • Application of ligustilide in elimination of quinolone drug residues in cultured fishes
  • Application of ligustilide in elimination of quinolone drug residues in cultured fishes

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Embodiment Construction

[0015] Test fish: channel catfish, average weight (180±32) g, purchased from Baishazhou Market, Wuhan, transported to the laboratory, placed in an aquarium (122cm×80cm×80cm) that had been cleaned and disinfected with potassium permanganate The medium was raised temporarily for 1 week, and the test water was tap water with sufficient aeration. After the respite, choose healthy individuals with uniform specifications for the test, and control the water temperature at 24±1°C.

[0016] Sarafloxacin (purity ≥ 98.0%, purchased from Shanghai Yuanye Biotechnology Co., Ltd.), artebolactone (purity ≥ 98.0%, purchased from Shanghai Yuanye Biotechnology Co., Ltd.).

[0017] The experiment was divided into two groups, one group was the control group of channel catfish sarafloxacin (oral dose of 20mg / kg fish body weight), the control group was orally administered sarafloxacin 12h and then oral administration of distilled water; the other group channel catfish After oral administration of s...

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Abstract

The invention discloses an application of ligustilide in elimination of quinolone drug (especially sarafloxacin) residues in cultured fishes. On the one hand, the ligustilide can reduce the concentration of quinolone drug residues in the cultured fishes, and on the other hand, the ligustilide can significantly shorten an elimination half-life period and a withdrawal period of the quinolone drugs in the cultured fishes. The ligustilide can be used for accelerating the accelerated elimination of quinolone chemical drug residues in cultured fish bodies, and has important significance for guaranteeing the quality safety of aquatic products and reducing the risk of taking in the aquatic products containing the quinolone chemical drug residues by human bodies.

Description

technical field [0001] The invention belongs to the technical field of aquatic animal pharmacology, and specifically relates to the application of artebenolactone in accelerating the elimination of quinolone drug residues (especially sarafloxacin) in cultured fish. Background technique [0002] Quinolones are a class of synthetic antibacterial drugs, which are widely used in the prevention and treatment of bacterial diseases in aquaculture animals because of their strong antibacterial power, broad antibacterial spectrum, and low price. With the rapid development of my country's aquaculture industry, the output of my country's aquatic products ranks first in the world, but also with the frequent occurrence of bacterial diseases in various aquatic animals, quinolones are used in large quantities. On the one hand, the bacterial diseases of aquatic animals have been eliminated. Treatment, on the other hand, also caused the problem of quinolone drug residues in aquatic products, c...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74A01K61/10A23K50/80A23K20/121
CPCG01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74A01K61/10A23K50/80A23K20/121G01N2030/324Y02A40/81
Inventor 刘永涛王桢月艾晓辉杨秋红董靖杨移斌周顺
Owner YANGTZE RIVER FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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