Interlaced sparse sampling multispectral photoacoustic tomography system and method

A technology of photoacoustic tomography and sparse sampling, which is applied in the fields of using spectrum diagnosis, using tomography for diagnosis, diagnosis, etc., and can solve problems such as sparse angle coverage density and difficulties in high-quality image reconstruction

Active Publication Date: 2020-08-04
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the reduced number of detectors, the angular coverage dens...

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  • Interlaced sparse sampling multispectral photoacoustic tomography system and method
  • Interlaced sparse sampling multispectral photoacoustic tomography system and method
  • Interlaced sparse sampling multispectral photoacoustic tomography system and method

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Embodiment 1

[0050] An interleaved sparse sampling multispectral photoacoustic tomography system, such as Figures 1 to 2 As shown, in the process of data acquisition, when the wavelength is switched, the sensor rotates around the imaging object to perform sparse sampling to realize the acquisition of photoacoustic signals corresponding to different angles at different wavelengths, and obtain sparse angle photoacoustic projection data.

[0051] The staggered sparse sampling multispectral photoacoustic tomography system of the present invention is provided with a sensor array module 1 and a mechanical rotation module 2 . The sensor array module 1 is used for collecting data of the imaging object, and is evenly distributed around the imaging object. The mechanical rotation module 2 drives the sensor array module 1 to rotate once around the imaging object during each wavelength switching period.

[0052] The sensor array module 1 of the present invention is provided with a plurality of ultra...

Embodiment 2

[0062] Interleaved sparse sampling multispectral photoacoustic tomography methods, such as image 3 As shown, the interleaved sparse sampling multispectral photoacoustic tomography system of Embodiment 1 is used, and the steps are as follows:

[0063] Step 1. Collect all sparse angle photoacoustic projection data in the data collection process, combine to obtain a set of dense projection data, and reconstruct the dense projection data to obtain a priori image;

[0064] Step 2. Under the guidance of the prior image obtained in step 1, respectively reconstruct the sparse angle photoacoustic projection data at each wavelength, and respectively obtain corresponding reconstructed photoacoustic images;

[0065] Step 3: Perform spectral separation on all the reconstructed photoacoustic images obtained in Step 2 to obtain images of individual distribution of each absorber.

[0066] in

[0067] Step 1 is specifically to collect all sparse angle photoacoustic projection data in the da...

Embodiment 3

[0083] A staggered sparse sampling multi-spectral photoacoustic tomography system, other features are the same as in Embodiment 1, the difference is that the laser emission module 3 of this embodiment has a laser, and the laser wavelength can be tuned in the range of 680nm to 980nm. In the example, lasers with five wavelengths of 700nm, 730nm, 760nm, 800nm ​​and 850nm are used, the sound velocity is set to 1536 m / s, and each projection contains 1105 samples.

[0084] The sensor array module 1 is that during wavelength switching, the sensor array rotates around the imaging object, and each rotation position collects photoacoustic projection data at a wavelength, and the sensor element has a center frequency of 5MHz and a bandwidth of 6dB.

[0085] In this embodiment, two kinds of sparse sampling are carried out: the first one is to select the number of transducers as Nd=21, the second one is to select Nd=16, and the projection angle that can cover the span of 270°, the radius is...

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Abstract

The invention discloses an interlaced sparse sampling multispectral photoacoustic tomography system. Sparse angle photoacoustic projection data are obtained by rotating a sensor around an imaging object; therefore, a high-quality reconstructed photoacoustic image and a high-precision spectrum separation result can be obtained under the condition that the number of sensors is greatly reduced, the production cost is greatly reduced, and an imaging system is simplified. According to the staggered sparse sampling multispectral photoacoustic tomography method, on the condition that number of sensors is reduced, projection data are obtained by using an interlaced sparse mode; a group of dense projections can be obtained by combining the interlaced sparse projection data acquired under each wavelength; the dense projection is reconstructed to finally obtain a high-quality priori image with good structural information, and sparse angle photoacoustic projection reconstruction is guided under each single wavelength by utilizing the priori image, thereby enhancing the reconstructed photoacoustic image and finally improving the spectrum separation precision.

Description

technical field [0001] The invention relates to the field of biomedical instruments, in particular to an interleaved sparse sampling multispectral photoacoustic tomography system and method. Background technique [0002] Photoacoustic tomography is a new hybrid imaging modality that detects broadband ultrasonic waves generated by elastic media absorbing pulsed light energy. By identifying changes in the absorption spectrum in a sequence of photoacoustic images acquired at multiple excitation wavelengths, multispectral photoacoustic tomography is able to separate the distribution of light absorbers in tissues and quantify their concentrations, with noninvasive imaging Ability. Photoacoustic tomography has great versatility and has been shown to visualize neuronal activity in the mammalian brain to detect, diagnose and treat disease, especially cancer. In addition, photoacoustic tomography is a promising imaging modality for diagnosing placental and fetal dysfunction and ass...

Claims

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Application Information

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IPC IPC(8): A61B5/00G06T11/00
CPCA61B5/0042A61B5/0073A61B5/0075A61B5/0095A61B5/4362A61B5/4848G06T11/003
Inventor 理喜盼戚力田昌敏张双阳吴建冯前进陈武凡
Owner SOUTHERN MEDICAL UNIVERSITY
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