Ubenimex recrystallization device and method thereof

Abstract

The invention discloses an ubenimex recrystallization device and a method thereof. The recrystallization device comprises a reaction kettle and a driving motor, and the driving motor is connected witha bevel gear transmission mechanism arranged in the reaction kettle through a main stirring shaft; the bevel gear transmission mechanism is composed of a main planet gear, at least one side planet gear and an auxiliary planet gear which are arranged from bottom to top, the side planet gear is connected with the main planet gear and the auxiliary planet gear respectively, and the main planet gearis connected with the main stirring shaft through a shaft; the auxiliary planetary gear is connected with the top end of the reaction kettle through a vertically-arranged auxiliary connecting shaft; and the side planetary gear is connected with the side wall of the reaction kettle through a horizontally-arranged side connecting shaft. According to the ubenimex recrystallization device, six-direction stirring can be achieved, the effect of dispersing gel is achieved, dead corners are greatly reduced, the problem that in the prior art, caking is likely to happen is solved, the production processis easier to control, and the quality is more stable; the product purity is improved, and the yield is also increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to an ubenimex preparation device, in particular to an ubenimex recrystallization device and a method thereof. Background technique [0002] Ubenimex is a compound isolated from the culture fluid of Streptomycesoforecticuli, which can competitively inhibit aminopeptidase B (aminopeptidaseN / CD13) and leucineamino-peptidase (Leucineamino-Peptidase). Ubenimex can enhance the function of T cells, enhance the killing activity of NK cells, and increase the synthesis of colony-stimulating factor to stimulate the regeneration and differentiation of bone marrow cells. This product can interfere with the metabolism of tumor cells, inhibit tumor cell proliferation, cause tumor cell apoptosis, activate human cellular immune function, stimulate the production and secretion of cytokines, promote the production and proliferation of anti-tumor effector cells, and be used for anti-cancer chemotherapy , ...

AI Technical Summary

Problems solved by technology

This method uses the crystallization method of one-way dropwise addition. When the pH of the system is 2 to 4, intermolecular polymers will be formed, which will cause instant agglomeration. Can't continue, and it's easy to damage the stirrer motor

The existing solution is to break up the gel manually, and add a large amount of purified water to dissolve the gel material to continue production, which not only affects production efficiency, but also reduces yield

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