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A composition and preparation method for multi-target suppression of melanin and its application in cosmetics

A technology for inhibiting melanin and composition, applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., can solve problems such as poisoning or leukoplakia, impossible additives, etc., to ensure safety, inhibit melanin content, and good inhibition effect Effect

Active Publication Date: 2021-09-24
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Substances such as mercury and hydroquinone have a strong inhibitory effect on tyrosinase, which can effectively reduce the synthesis of melanin, but due to their toxicity and strong enzyme inhibitory effect, they are often prone to adverse consequences such as poisoning or white spots after use. They are no longer possible as additives in skin care products

Method used

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  • A composition and preparation method for multi-target suppression of melanin and its application in cosmetics
  • A composition and preparation method for multi-target suppression of melanin and its application in cosmetics
  • A composition and preparation method for multi-target suppression of melanin and its application in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This example provides a composition and preparation method for multi-target inhibition of melanin:

[0030] (1) Preparation of Ligusticum chuanxiong extract: dry the Chinese medicine Ligusticum chuanxiong to constant weight, crush it through a 60-mesh sieve, add it into an ethanol solvent with a volume fraction of 50% according to the ratio of solid to liquid in g:mL as 1:5, and heat and reflux to extract 2 time, each 2h, combined filtrate, rotary evaporation to remove solvent, and freeze-drying to obtain the Rhizoma Chuanxiong extract;

[0031] Preparation of peony extract: dry peony to constant weight, crush through a 60-mesh sieve, add it into ethanol solvent with a volume fraction of 50% according to the ratio of solid to liquid (g:mL) as 1:15, heat and reflux for extraction twice, each time 2h, the filtrates were combined, the solvent was removed by rotary evaporation, and freeze-dried to obtain the peony extract;

[0032] Preparation of vine tea extract: dry vine...

Embodiment 2

[0047] This example provides a composition and preparation method for multi-target inhibition of melanin:

[0048] (1) Preparation of Ligusticum chuanxiong extract: dry the Chinese medicine Ligusticum chuanxiong to constant weight, pulverize through a 60 mesh sieve, add it into an ethanol solvent with a volume fraction of 50% according to the ratio of material to liquid in g:mL as 1:15, and heat and reflux to extract 2 time, each 2h, combined filtrate, rotary evaporation to remove solvent, and freeze-drying to obtain the Rhizoma Chuanxiong extract;

[0049] Preparation of peony extract: dry peony to constant weight, crush through an 80-mesh sieve, add it into ethanol solvent with a volume fraction of 50% according to the ratio of solid to liquid (g:mL) as 1:15, heat and reflux for extraction twice, each time 2h, the filtrates were combined, the solvent was removed by rotary evaporation, and freeze-dried to obtain the peony extract;

[0050] Preparation of vine tea extract: dr...

Embodiment 3

[0065] This example provides a composition and preparation method for multi-target inhibition of melanin:

[0066] (1) Preparation of Ligusticum chuanxiong extract: dry the Chinese medicine Ligusticum chuanxiong to constant weight, crush it through an 80 mesh sieve, add it into an ethanol solvent with a volume fraction of 50% according to the ratio of solid to liquid in g:mL as 1:20, and heat and reflux to extract 2 time, each 2h, combined filtrate, rotary evaporation to remove solvent, and freeze-drying to obtain the Rhizoma Chuanxiong extract;

[0067] Preparation of peony extract: dry peony to constant weight, crush through an 80-mesh sieve, add it into ethanol solvent with a volume fraction of 50% according to the ratio of solid to liquid (g:mL) as 1:15, heat and reflux for extraction twice, each time 2h, the filtrates were combined, the solvent was removed by rotary evaporation, and freeze-dried to obtain the peony extract;

[0068] Preparation of vine tea extract: dry v...

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Abstract

The invention discloses a composition and preparation method for multi-target inhibition of melanin and its application in cosmetics. In total, the chuanxiong extract is 30-60%, the peony extract is 20-40%, and the rattan tea extract is 10-40%. Inhibition of melanin by the prescription of the present invention is embodied in the form of multiple targets, and the prescription can ensure safety while ensuring the effect of suppressing melanin content.

Description

technical field [0001] The invention belongs to the technical field of cosmetic preparation, and in particular relates to a multi-target melanin-inhibiting composition, a preparation method and its application in cosmetics. Background technique [0002] Melanin is synthesized by melanocytes in the basal layer of the human epidermis. When melanocytes are subjected to exogenous stimuli (forskolin, IBMX) and endogenous stimuli α-MSH, a series of reactions in the cells will be induced, resulting in the synthesis of melanin in the cells. Gene expression and protein synthesis (tyrosinase, etc.), eventually lead to the increase of melanin content. [0003] Traditional Chinese medicine has been used in my country for thousands of years. Compared with single traditional Chinese medicine, the combination of traditional Chinese medicine can improve the efficacy, resist disinfection, help damage repair, and better exert its curative effect. Substances such as mercury and hydroquinone h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q19/02
CPCA61K2800/5922A61Q19/02A61K8/9789
Inventor 孙培冬王勇恒杨成
Owner NINGBO YUFANGTANG BIOTECH
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