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Application of fucosan sulfate in promoting autophagy of foam cells to decompose ox-LDL

A technology of fucoidan sulfate and foam cells, which is applied to medical preparations containing active ingredients, organic active ingredients, and pharmaceutical formulas, can solve problems such as the mechanism of action that has not been reported, and achieve the effect of preventing and curing arteriosclerosis

Active Publication Date: 2020-06-05
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of fucoidan sulfate on foam cells and its mechanism of action have not been reported.

Method used

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  • Application of fucosan sulfate in promoting autophagy of foam cells to decompose ox-LDL
  • Application of fucosan sulfate in promoting autophagy of foam cells to decompose ox-LDL
  • Application of fucosan sulfate in promoting autophagy of foam cells to decompose ox-LDL

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] Foam cell model was constructed using macrophage RAW264.7:

[0034] Set the density to 5×10 4 Each / mL RAW264.7 was inoculated in 96-well plate / 24-well plate, and 0, 20, 40, 80, 100, 120 μg / mL ox-LDL was given after 24 hours of attachment, and after co-incubating for 24 hours, oil red O Lipid droplet staining and cholesteryl ester content determination were carried out with the cholesterol kit respectively. figure 1 and figure 2 The suitable modeling concentration of foam cells was determined to be 80μg / mL.

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Abstract

The invention discloses an application of fucosan sulfate in promoting autophagy of foam cells to decompose ox-LDL, belonging to the technical field of pharmaceutical preparations. The fucosan sulfatecan promote cell autophagy to decompose excessive ox-LDL in the foam cells, so a new direction is provided for the foam cells to recover to normal macrophages, and a new idea is provided for application of the fucosan sulfate.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to the application of fucoidan sulfate in promoting foam cell autophagy to decompose ox-LDL. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] With the aging of society and the acceleration of urbanization, the prevalence of unhealthy lifestyles among residents and the increasing incidence of cardiovascular and cerebrovascular diseases (CVD) have become a worldwide problem. Atherosclerosis (AS) is the common basis of cardiovascular and cerebrovascular events such as myocardial infarction and cerebral infarction, and the mechanism of AS is complex and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P9/10
CPCA61K31/737A61P9/10A61P43/00
Inventor 宋淑亮吉爱国
Owner SHANDONG UNIV
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