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Applications of NO and/or NO donor in preparation of drug for preventing and/or assisting to treat open-angle glaucoma and drug

A technology of adjuvant treatment for open-angle glaucoma, which is applied in the field of medicine and can solve problems such as unclear pathogenesis and no good preventive measures for open-angle glaucoma

Pending Publication Date: 2020-05-12
罗辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Glaucoma is still the main blinding eye disease, its pathogenesis, especially open-angle glaucoma, the pathogenesis is not clear, and there are no good preventive measures for open-angle glaucoma

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Drugs include NO and water, the concentration of NO is 1×10 -4 mol / L. This medication is in the form of nasal drops.

Embodiment 2

[0047] The drug consists of isosorbide dinitrate and water, the concentration of isosorbide dinitrate is 1×10 -7 mol / L. This medication is in the form of nasal drops.

Embodiment 3

[0049] The drug includes NO and 0.08vol% sodium hyaluronate aqueous solution, the concentration of NO is 8×10 -5 mol / L. This medication is in the form of nasal drops.

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PUM

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Abstract

The invention provides applications of NO and / or NO donor in preparation of a drug for preventing and / or assisting to treat open-angle glaucoma and the drug, and relates to the technical field of medicines. The administration characteristic of the drug is intranasal administration; the NO has the efficacy of adjusting blood circulation, promoting the recovery of trabecular functions and adjustingimmunity to promote inflammation to subside, so that intraocular pressure can be prevented or reduced; and in addition, the NO can also take part in adjusting systemic arteriovenous pressure and cerebrospinal fluid pressure, so that pressure across sieve plates can be affected so as to affect the development and outcome of the open-angle glaucoma.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application and medicine of NO and / or NO donor in the preparation of medicine for preventing and / or assisting the treatment of open-angle glaucoma. Background technique [0002] Glaucoma is still the main blinding eye disease, its pathogenesis, especially open-angle glaucoma, the pathogenesis is not clear, open-angle glaucoma is currently no good preventive measures. [0003] The current study found that patients with open-angle glaucoma have decreased ocular perfusion pressure, decreased blood flow in the optic disc, retina, choroid and retrobulbar vessels, and clinical manifestations such as vasospasm or vascular endothelial dysfunction. Risk factors include family history, high blood pressure, diabetes, smoking and many other factors. These factors were also associated with vascular factors. CTGF, TNF-α, various interleukins, NF-κB and other cytokines are highly express...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K33/26A61K31/21A61K9/00A61K47/36A61K47/38A61K47/32A61P27/06
CPCA61K9/0043A61K31/21A61K33/26A61K45/00A61K47/32A61K47/36A61K47/38A61P27/06
Inventor 罗辉
Owner 罗辉
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