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Diagnosis and risk stratification of fungal infections

A technology for risk stratification and in vitro diagnosis, applied in the field of diagnostic assays and kits, which can solve problems such as undisclosed pro-adrenomedullin, undisclosed diagnosis, etc.

Pending Publication Date: 2020-04-21
BRAHMS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the suitability of proadrenomedullin (proADM) or partial peptides or fragments thereof, in particular midregional proadrenomedullin (MR-proADM) for the diagnosis of IFI / IFD is not disclosed, nor is it disclosed in relation to sepsis or Diagnosis of IFI / IFD associated with septic shock

Method used

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  • Diagnosis and risk stratification of fungal infections
  • Diagnosis and risk stratification of fungal infections
  • Diagnosis and risk stratification of fungal infections

Examples

Experimental program
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Embodiment 1

[0113] Research design. The observational clinical study was approved by the local ethics committee (Ethics Committee of Heidelberg Medical School, Trial Code S-097 / 2013 / German Clinical Trials Register: DRKS00005463) and was conducted in Germany between November 2013 and January 2015 Performed in the Surgical Intensive Care Unit of the University Hospital Heidelberg. All study patients or their legal representatives signed the informed consent. In this study, a total of 50 patients with sepsis were recruited according to the criteria of Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock 2012. Patients with hemorrhagic shock (Dellinger RP, Levy MM, Rhodes A, etc., (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septicshock: 2012. Crit Care Med41: 580-637). Treatment of patients with septic shock includes early goal-directed therapy (Romani L (2004) Immunity to fungal infections. "...

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PUM

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Abstract

The invention relates to a method for the diagnosis and / or risk stratification of invasive fungal infections (IFI) / invasive fungal diseases (IFD) and in particular associated with sepsis or septic shock, wherein a determination of the marker proadrenomedullin (proADM) or a partial peptide or fragment thereof, in particular midregional proadrenomedullin (MR-proADM), or contained in a marker combination (panel, cluster), is carried out from a patient to be examined. Furthermore, the invention relates to a diagnostic assay and a kit for carrying out the method.

Description

technical field [0001] The present invention relates to a method for the diagnosis and / or risk of fungal infections, particularly invasive fungal infections (hereinafter abbreviated as "IFI") and invasive fungal diseases (hereinafter abbreviated as "IFD") associated with sepsis or septic shock Stratified approach, wherein the marker proadrenomedullin (proADM) or partial peptides or fragments thereof, in particular midregional proadrenomedullin (MR-proADM), is determined from the patient to be examined, or is included in a marker combination Those in (group, cluster). Furthermore, the invention relates to diagnostic assays and kits for carrying out said methods. Background technique [0002] Said precursor peptide inter alia contains a signal sequence of 21 amino acids at the N-terminus and is called "pro-adrenomedullin pre-pro-peptide" (pre-proADM) (Kitamura K, Sakata J, Kangawa K, Kojima M, Matsuo H, Eto T. Cloning and characterization of cDNA encoding a precursor for hum...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/74
CPCG01N33/68G01N33/74G01N2800/26G01N33/6893G01N2333/525G01N2333/5412G01N2333/5428G01N2333/57G01N2800/50G01N2800/52
Inventor T·博内尔M·A·维甘德F·乌勒D·C·威尔森
Owner BRAHMS GMBH
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