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A kind of phenylpropanoid compound and preparation method thereof

A compound, phenylpropanoid technology, applied in organic chemistry, drug combination, pharmaceutical formula, etc., can solve the problem of less anticoagulant active ingredients, and achieve the effect of good biological activity, high purity, and strong inhibitory activity

Active Publication Date: 2021-03-23
FUJIAN SANAN SINO SCI PHOTOBIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to reports, the research on this medicinal material mainly focuses on the procoagulant or hemostatic effect of this medicinal material, and there are few studies on the anticoagulant active ingredients in this medicinal material

Method used

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  • A kind of phenylpropanoid compound and preparation method thereof
  • A kind of phenylpropanoid compound and preparation method thereof
  • A kind of phenylpropanoid compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A preparation method for phenylpropanoid compounds, comprising the steps of:

[0056] Source of material: Pleurotus chinensis was purchased from Luyuan Biotechnology Co., Ltd., and the specimen samples of this medicinal material are preserved in the Pharmacy Department of Drug Research and Development Center of Fujian Zhongke Biological Co., Ltd.

[0057] (1) Use the above-ground part of Pinus chinensis as raw material, dry and pulverize 10 kg of the obtained coarse powder, extract the coarse powder with 100 L, 60% ethanol aqueous solution, and rotate the obtained extract to dryness to obtain 980 g of crude extract;

[0058] (2) Use an appropriate amount of pure water to dissolve the extract to make an aqueous solution with a concentration of 50 mg / mL, then use chloroform and n-butanol to extract respectively, specifically according to the ratio of organic phase:water phase = 4:1 (v / v), Adopt the vibration amplitude of oscillator 120rpm to shake for 15min and stand stil...

Embodiment 2

[0067] A preparation method for phenylpropanoid compounds, comprising the steps of:

[0068] (1) Using the above-ground part of Duanxueliu (Campanthia chinensis) as raw material, the dried sample was pulverized to obtain 5 kg, and then extracted with 50 L, 60% methanol aqueous solution, and the obtained extract was rotary evaporated to dryness to obtain 480 g of crude extract;

[0069] (2) Take 450g of the crude extract extract and use pure water to make an aqueous solution with a concentration of 100mg / mL, and then use chloroform and n-butanol to extract respectively, specifically according to the ratio of organic phase:water phase=4:1 (v / v) For extraction, use an oscillator with an amplitude of 120 rpm to shake for 15 minutes and then stand still for 4 hours, extracting three times in total to obtain 145 g of n-butanol extract;

[0070] (3) Get 130g of n-butanol extract, use D101 macroporous adsorption resin column chromatography, carry out with 0%, 20%, 45%, 70%, 100% (v / v)...

Embodiment 3

[0075] A preparation method for phenylpropanoid compounds, comprising the steps of:

[0076] (1) Using the above-ground part of the off-the-blood medicinal material (Campanthia chinensis) as a raw material, the dried sample was pulverized to obtain 5 kg of coarse powder, which was extracted with 70% ethanol aqueous solution, and the obtained extract was rotary evaporated to dryness to obtain 430 g of crude extract;

[0077] (2) Take 410g of the crude extract and use pure water to make an aqueous solution with a concentration of 100mg / mL, and then use chloroform and n-butanol to extract respectively, specifically according to the organic phase:water phase=4:1 (v / v) Proportional extraction, using a shaker at 120 rpm for 15 minutes and then standing still for 4 hours, extracted three times in total to obtain 135 g of n-butanol extract;

[0078] (3) Get 125g of n-butanol extract, use D101 macroporous adsorption resin column chromatography, carry out with 0%, 30%, 60%, 85%, 100% (v...

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Abstract

The invention discloses a phenylpropanoid compound, a preparation method and applications thereof, wherein the molecular formula of the compound is C27H22O10, and the molecular weight is 506. According to the invention, the compound obtained through the preparation method is high in purity and good in stability, and has good biological activity, wherein the purity reaches 98%; and the results of the in-vitro blood coagulation activity experiment method show that the compound has strong inhibitory activity on thrombin-activated platelet aggregation, and has the potential in development of anticoagulant drugs or antithrombotic drugs and medical equipment.

Description

technical field [0001] The invention belongs to the technical field of natural product chemistry, and in particular relates to a compound isolated from Campanula chinensis and its preparation method and medical application. The molecular formula of the compound is C 27 h 22 o 10 , the molecular weight is 506. Background technique [0002] There are more than 20 species of plants in the genus Clinopodium Linn. of the Labiatae family, mainly distributed in Europe, Central Asia and eastern Asia. Fengluncai and Yinfenglun were recorded in the 2010 edition of "Chinese Pharmacopoeia" as medicine for cutting off blood flow. They have the effect of astringent and hemostasis. Simple purpura, idiopathic thrombocytopenic purpura and other diseases. Our country is rich in resources of medicinal plants of the genus Campania, and has a long history of medicinal use among the people, so it has broad prospects for development and utilization. [0003] The broken blood stream is the dry...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/86A61K31/343A61P7/02
CPCA61P7/02C07D307/86
Inventor 占卓雷绍南单世斌苏丽辉王佩忠
Owner FUJIAN SANAN SINO SCI PHOTOBIOTECH CO LTD
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