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COPD early diagnosis marker and application thereof

A technology of early diagnosis and markers, applied in the field of medicine, can solve problems that cannot be cured, cannot be predicted early, and are progressively exacerbated

Active Publication Date: 2020-01-07
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] To sum up, the morbidity and mortality of COPD have been increasing year by year in recent years, and it is still impossible to predict early clinically. Once diagnosed, it will be progressively aggravated and cannot be cured, causing serious family economic burden and social health problems.
However, as a complex disease caused by the interaction of polygenic inheritance and environmental factors, COPD has no clinically effective risk prediction markers so far.

Method used

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  • COPD early diagnosis marker and application thereof
  • COPD early diagnosis marker and application thereof
  • COPD early diagnosis marker and application thereof

Examples

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Embodiment 1

[0112] 1. Utilize the mRNA gene expression profiling chip containing the peripheral blood of healthy controls of different ages to screen aging-related genes.

[0113] (1) Screen aging databases: In NCBI, use "aging" and "senescence" as keywords to search for databases whose species are human and whose samples are peripheral blood / peripheral blood mononuclear cells. The exclusion criteria were: 1. Lack of specific age information of the research subjects; 2. The research subjects suffered from definite diseases or received certain interventions during the study; 3. The sample size was less than 30. The three databases finally included are GSE58137, GSE65219, and GSE74786.

[0114] (2) Screening of aging-related genes: the adjusted linear regression model was used to analyze the differentially expressed genes with aging in the three databases, and then the differentially expressed genes generated by the three databases were intersected through the Venn diagram to obtain the agi...

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Abstract

The invention relates to the technical field of drugs, in particular to a biomarker for COPD and application of the biomarker, and provides a COPD early diagnosis drug marker and a diagnostic drug kitcontaining the marker. The marker is eight senescence-related genes differentially expressed in the COPD: one or any combination of FOXO3, TP53, TGF<beta>1, HDAC1, NUF2, ATG3, AREG and E2F1, or one or any combination of 13 methylation loci of the senescence-related genes differentially expressed in the COPD. The degree of methylation of the marker in a control group and a COPD group is statistically significant (P<0.05), and the marker can be used as the biomarker in the diagnosis of the clinical COPD.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a biomarker for identifying chronic obstructive pulmonary disease and its detection application. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a disease state characterized by not fully reversible airflow limitation, which is usually progressive, and its pathological feature is persistent airflow obstruction and persistent exacerbation of airway inflammation. COPD is one of the diseases with high morbidity and mortality in the world, and its incidence is gradually increasing. It is predicted that by 2020, COPD will become the third leading cause of death in the world, and it will bring serious health burden to the world in terms of morbidity, hospitalization rate and medical treatment. It is particularly worth noting that at this stage, the susceptibility risk screening and early diagnosis of COPD are very difficult, and there is no effective tr...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/154C12Q2600/156C12Q2600/158
Inventor 刘持秦岭袁琳杜茜子秦晓群向阳瞿湘萍刘惠君
Owner CENT SOUTH UNIV
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