Chinese medicinal composition containing recombinant hirudin for treating hyperplasia of mammary glands and preparation method thereof

A technology for recombining hirudin and mammary gland hyperplasia, which is applied in the directions of drug combination, pharmaceutical formula, active ingredient of hydroxyl compound, etc., can solve the problems of increasing the burden on the gastrointestinal tract and other organs, the first-pass effect of the liver, and the reduction of drug efficacy, etc. The effects of relieving or curing breast swelling or pain, prolonging storage time, and stabilizing physical and chemical properties

Pending Publication Date: 2020-01-03
云山化妆品研究开发(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine treatment of mammary gland hyperplasia mostly adopts internal treatment, that is, oral Chinese medicine or Chinese patent medicine. Although the curative effect is exact, the decoction of Chinese medicine is inconvenient and oral administration may cause liver first-pass effect. In addition to gastrointestinal digestion, the efficacy of the medicine will be discounted. A longer treatment period will also increase the burden on organs such as the gastrointestinal tract

Method used

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  • Chinese medicinal composition containing recombinant hirudin for treating hyperplasia of mammary glands and preparation method thereof
  • Chinese medicinal composition containing recombinant hirudin for treating hyperplasia of mammary glands and preparation method thereof
  • Chinese medicinal composition containing recombinant hirudin for treating hyperplasia of mammary glands and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0039] (1) Soak the preparation raw materials of the Chinese medicine components in cold water, and dry them for subsequent use;

[0040] (2) Put the product obtained in step (1) into distilled water for cooking, filter to obtain filtrate and filter residue, and concentrate the filtrate to obtain component A extract;

[0041] (3) Put the filter residue in step (2) into the mixed solution of ethanol\distilled water, reflux extraction, and concentrate to obtain the B component extract, to get final product, the volume ratio of the ethanol and distilled water is 1:(3~5 ).

[0042] Zeeland

[0043] Also known as sweet potato seedlings, ground bamboo shoots, mannose, and euphemum; this product is the dry aerial part of Lycopuslucidus Turcz.var.hirtus Regel, a plant of the Labiatae family. Harvested in summer and autumn when the stems and leaves are flourishing, and dried in the sun. The traditional Chinese medicinal herb Eupatorium is the dry aboveground part of sweet potato see...

Embodiment 1

[0160] Embodiment 1 of the present invention provides a Chinese medicine composition containing recombinant hirudin for the treatment of mammary gland hyperplasia, comprising 7% of the water phase component, 1.5% of the oil phase component, 10% of the recombinant hirudin Hirudin fermentation broth, 1% of traditional Chinese medicine components, 0.6% of auxiliary agents and the rest of water;

[0161] The water phase components include small molecule alcohol and complexing agent, the weight ratio of small molecule alcohol and complexing agent is 1:0.006;

[0162] The small molecule alcohol is 1,3-butanediol and 1,2-hexanediol, the weight ratio of 1,3-butanediol and 1,2-hexanediol is 1:0.1; the complexing agent is disodium EDTA ;

[0163] The water phase component also includes arginine; the weight ratio of arginine to complexing agent is 1:1.5;

[0164] The oil phase component is a humectant, and the humectant is xylitol, xanthan gum, and sodium hyaluronate, and the weight ra...

Embodiment 2

[0199] Embodiment 2 of the present invention provides a traditional Chinese medicine composition containing recombinant hirudin for the treatment of hyperplasia of mammary glands. According to the weight percentage of the composition, it includes 10% of the water phase component, 3% of the oil phase component, 15% of the Recombinant hirudin fermentation broth, 2% of traditional Chinese medicine components, 1% of auxiliary agents and the rest of water;

[0200] The water phase components include small molecule alcohol and complexing agent, the weight ratio of small molecule alcohol and complexing agent is 1:0.01;

[0201] The small molecule alcohol is 1,3-butanediol and 1,2-hexanediol, the weight ratio of 1,3-butanediol and 1,2-hexanediol is 1:0.2; the complexing agent is disodium EDTA ;

[0202] The water phase component also includes arginine; the weight ratio of arginine to complexing agent is 1:1.6;

[0203] The oil phase component is a humectant, and the humectant is xyl...

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Abstract

The invention relates to the related technical field of treatment of hyperplasia of mammary glands, in particular to a traditional Chinese medicine composition containing recombinant hirudin for treating hyperplasia of mammary glands and a preparation method thereof. According to a first aspect, the traditional Chinese medicine composition containing the recombinant hirudin for treating the hyperplasia of mammary glands is provided, and is prepared from the components in percentage by weight: 3%-10% of an aqueous phase component and 0.5%-3% of an oil phase component,5%-15% of recombinant hirudin fermentation broth, 0.5%-2% of traditional Chinese medicine components, 0.2%-1% of an assistant and the balance of water. According to the traditional Chinese medicine composition containing the recombinant hirudin for treating the hyperplasia of mammary glands, a technical solution combining the recombinant hirudin fermentation broth and the traditional Chinese medicine components is used, mammary swelling or swelling pain can be relieved or cured in a short time, in addition, the composition has stable physical and chemical properties, the storage stability is good, and the storage time of related products can be better prolonged.

Description

technical field [0001] The invention relates to the related technical field of mammary gland hyperplasia treatment, more specifically, the invention provides a traditional Chinese medicine composition containing recombinant hirudin for treating mammary gland hyperplasia and a preparation method thereof. Background technique [0002] Mammary gland hyperplasia is a common clinical disease and frequently-occurring disease, and its incidence rate accounts for the first among breast diseases. It is the physiological hyperplasia and incomplete involution of normal mammary gland lobules, and the normal structure of mammary gland is disordered. It belongs to pathological hyperplasia and is neither inflammation nor tumor benign disease. The age of onset is concentrated in 20-50 years old, and its incidence rate accounts for about 40% of women of childbearing age and 75% of all breast diseases. The risk of breast cancer is 2-3 times higher than that of healthy women. Due to the long ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/58A61P15/14A61K31/045
CPCA61K36/53A61K36/28A61K36/756A61K36/708A61K31/045A61K36/233A61K36/236A61K36/71A61K36/65A61K36/58A61K36/9066A61K36/902A61K36/8905A61K36/288A61K36/484A61K36/232A61K36/66A61K36/428A61K36/324A61K36/328A61K38/58A61P15/14A61K2300/00
Inventor 杨爱岗胡云山
Owner 云山化妆品研究开发(广州)有限公司
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