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Prognostic prediction method for non-small cell lung cancer

A technology of non-small cell lung cancer and prediction method, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of inconsistent prognostic effect and no prognostic effect, etc.

Pending Publication Date: 2019-12-27
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Currently, there are only studies on ACSS2 in renal cell carcinoma, bladder cancer, gastric cancer, and liver cancer, and the prognostic role is inconsistent, but there is no related research on the prognostic role of ACSS2 pS659 in tumors

Method used

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  • Prognostic prediction method for non-small cell lung cancer
  • Prognostic prediction method for non-small cell lung cancer
  • Prognostic prediction method for non-small cell lung cancer

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Embodiment 1

[0019] The term "prognosis" referred to in the present invention means to provide a prediction of the likely course and outcome of cancer. It not only includes judging the specific consequences of the disease (such as recovery, the appearance or disappearance of certain symptoms, signs, complications and other abnormalities, and death), but also provides time clues, such as predicting the possibility of a certain outcome within a certain period of time . Prognosis can include cancer complications, likelihood of metastasis, spread, likely outcome of the cancer, likelihood of recovery, overall survival and / or overall mortality. Preferably, the prognosis is the probability of the patient recovering or having a recurrence / recurrence of the cancer. For example, "good prognosis" means that the cancer is less prone to recurrence and metastasis, and "poor prognosis" means that the cancer is more prone to recurrence and metastasis. Example 1 Correlation between single or combined app...

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Abstract

The invention provides a prognostic prediction method for a non-small cell lung cancer. The prognostic prediction method comprises the step of detecting phosphorylation levels of fructokinase A and anS659 site of acetyl-coenzyme A synthase kinase 2 of a cancer cell. According to the prognostic prediction method, the phosphorylation expression levels of the fructokinase A and / or the S659 site of the acetyl-coenzyme A synthase kinase 2 are detected through an immunohistochemical technique on the basis of phosphorylation of the fructokinase A and / or the S659 site of the acetyl-coenzyme A synthase kinase 2, and the survival time of the non-small cell lung cancer is independently predicted.

Description

technical field [0001] The invention relates to the field of oncology, in particular to a method for predicting prognosis in non-small cell lung cancer based on phosphorylation at S659 site of fructokinase A and acetyl-CoA synthesis kinase 2. Background technique [0002] Tumor metabolic reprogramming is a very important feature of tumors. During the process of tumor metabolic reprogramming, tumor metabolism transforms to anabolism, providing more favorable products and environments for the growth of tumor cells. In recent years, studies have shown that phosphorylation of fructokinase A (KHK-A) and acetyl-CoA synthetic kinase 2 at S659 (ACSS2 pS659) not only plays the role of metabolic enzymes, but also plays the role of non-metabolic enzymes in tumor metabolic reprogramming , thereby promoting the development of tumors. [0003] In hepatocellular carcinoma, KHK-C (fructokinase C) is converted to KHK-A, and KHK-A phosphorylates downstream genes to promote nucleic acid synth...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/573
CPCG01N33/57423G01N33/57484G01N33/573G01N2333/91215
Inventor 赫捷吕志民高亦博杨雪莹
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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