High-efficiency chemical biological agent and its application for removing Pseudomonas aeruginosa biofilm

Abstract

The invention discloses a high-efficiency chemical biological preparation for removing Pseudomonas aeruginosa biofilm, which comprises the following components: 60%-75% of microbial preparation and 25% of active oxygen free radical scavenger ~40%; the microbial preparation is ΔLasR strain and / or ΔLasI strain. The high-efficiency chemical biological agent for removing Pseudomonas aeruginosa biofilm of the present invention has the advantages of being green, economical, universal, and durable, and has a simple formula, and the ingredients used are low in price and have a wide range of sources, and are low-cost and effective. A formulation that inhibits the growth of Pseudomonas aeruginosa and its film formation.

Description

technical field [0001] The invention relates to the field of membrane pollution removal, in particular to a high-efficiency chemical biological agent for removing Pseudomonas aeruginosa biofilm and application thereof. Background technique [0002] Biofilms, also known as biofilms, are aggregates of organized growth of microorganisms. Composed of lipids, proteins, and sugars, bacterial biofilms confer strong physical resistance to antibiotics and facilitate the disruption of host immune defense mechanisms. When biofilm forms on domestic pipelines, industrial production, and medical equipment, it will cause erosion and blockage of pipelines, pollute products, reduce heat conduction, and cause bacterial infections, etc., which will bring many problems to production and life. [0003] Pseudomonas aeruginosa (P.a) is widely distributed in nature and exists in various moist environments, such as water, air, human skin, respiratory tract and intestinal tract. In many actual prod...

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Problems solved by technology

[0005] Existing methods for removing and inhibiting biofilm formation: the Chinese invention patent with the notification number CN105613584B discloses a method for improving the removal and sterilization efficiency of silver ions on biofilm, through a small molecular substance that has a dissociation effect on biofilm Bis(3-aminopropyl)amine is coupled with silver ions, which improves the efficiency of inorganic silver ions on biofilm removal and sterilization, but the raw materials of this invention contain high-cost materials such as inorganic silver ions and bis(3-aminopropyl)amine , not suitable for commercial production; the Chinese invention patent with the notification number CN1901801B discloses that gallium inhibits the formation of biofilms, and coating the equipment or equipment surface with a gallium-containing composition at a concentration sufficient to inhibit the formation of biofilms has a significant effect, but The preparation process of the gallium-containing composition is cumbersome

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