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Novel antitumor composition, preparation and application

A technology of anti-tumor drugs and compositions, which is applied in the field of medicine, can solve problems such as patent publications that have not yet been found, and achieve the effects of significant inhibition of cell proliferation, improvement of efficacy, and reduction of toxic and side effects

Inactive Publication Date: 2019-12-03
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Novel antitumor composition, preparation and application
  • Novel antitumor composition, preparation and application
  • Novel antitumor composition, preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] To study the inhibitory effects of single drugs topotecan and crizotinib on the proliferation of H1975, HCC827 and H1299 cells. 50 The values ​​are shown in Table 1.

[0058] Table 1 IC of single drug topotecan and crizotinib on lung cancer cells 50 value

[0059]

Embodiment 2

[0061] The experimental results of different concentrations of single drug topotecan and crizotinib and their combinations on H1975 cell proliferation inhibition are shown in figure 1 , the CI value of the composition see figure 2 . From figure 1 and figure 2 It can be seen that the CI of the combination is less than 1, indicating that the combination has good superiority over the single drug.

Embodiment 3

[0063] The experimental results of different concentrations of single drug topotecan and crizotinib and their compositions on the inhibition of HCC827 cell proliferation are shown in image 3 , the CI value of the composition see Figure 4 . From image 3 and Figure 4 It can be seen that the CI of the combination is <1, indicating that the combination has good superiority over the single drug.

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Abstract

The invention relates to a novel antitumor composition. The composition is the composition of topotecan and crizotinib. According to the combination medicines, the topotecan and the crizotinib are combined for use, and the composition being low in effective dose has notable synergy effects for treatment of non-small cell lung cancer, particularly has synergy effects in the respect of treating non-small cell lung cancer. In vivo experimentation on animals also primarily confirms that the combined medicines are notable in inhibition effects on cell proliferation, the tumor inhibition effects areincreased, a new thought is provided for treatment of patients when generating reverse tolerance of the non-small cell lung cancer, and scientific basis is provided for research and development of new medicines.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a novel antitumor drug composition, preparation and application. Background technique [0002] Lung cancer is the number one malignant tumor that threatens human health in the world today. This kind of malignant tumor not only has a very high incidence rate, but also has a poor prognosis. The occurrence of lung cancer is mainly due to the unregulated growth of lung tissue cells, which leads to metastasis and infiltration of surrounding tissue cells, which seriously endangers human life. [0003] Lung cancer can be divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), more than 80% of which are non-small cell lung cancer. In non-small cell lung cancer, about 65% of patients have developed local progression or distant metastasis at the time of first diagnosis. At present, with the discovery of mutated genes in non-small cell lung cancer, molecular ta...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61K31/4545A61P35/00
CPCA61K31/4545A61K31/4745A61P35/00A61K2300/00
Inventor 刘振郁彭滕玉鸥殷盼盼邱亚楠崔丽付青山
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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