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New use of drug nifedipine

A technology of nifedipine and its use, which is applied in the field of medicine, can solve problems such as being unknown, and achieve the effects of preventing nicotine addiction, reducing research costs, and preventing relapse

Inactive Publication Date: 2019-11-29
中国医科大学
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Problems solved by technology

Combining the existing technologies, these two articles can only conclude that the different subtypes of L-type calcium ion channels have certain roles in regulating the firing behavior of cells in the ventral dorsal tegmental area of ​​the midbrain and in inducing nicotine-mediated conditioned place preference behavior. However, whether the drug nifedipine and other L-type calcium ion channel antagonists are useful for the prevention and treatment of nicotine addiction, whether they can help nicotine addicted patients quit smoking and prevent relapse, is still unknown

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  • New use of drug nifedipine
  • New use of drug nifedipine
  • New use of drug nifedipine

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Embodiment Construction

[0025]In the study of the low success rate of existing drugs for the treatment of nicotine addiction, the use of well-recognized behavioral experiments on drug addiction (conditioned place preference test and behavioral sensitization test) found that nifedipine prevents nicotine addiction At the same time, the electrophysiological recording technology in the brain was further used to evaluate the specific brain regions of the therapeutic effect of nifedipine, which provided detailed and sufficient data support for nifedipine as a drug for the prevention and treatment of nicotine addiction. The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0026] Experimental materials: C57 / B6J mice were purchased from the Animal Center of China Medical University, all male, for 8 weeks; nicotine, purchased from Glentham Life Science; nifedipine, diltiazem, and verapamil, purchased from Dalian Meilun Biotechnology Ltd. The mo...

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Abstract

The invention discloses a new use of nifedipine, or medically acceptable salts, esters and solvates of nifedipine in preparation of drugs for preventing and / or treating nicotine addiction, and belongsto the field of pharmaceutical technology. The use of taking nifedipine as drugs for preventing and / or treating nicotine addiction has the following advantages: (1) nifedipine can prevent nicotine addiction, accelerate a withdrawal process and prevent relapse, and the effect is obvious; (2) drug resistance on nifedipine in the aspect of preventing and treating nicotine addiction is avoided; (3) nifedipine is a clinically available drug, so that in research of drugs for preventing and / or treating nicotine addiction, cost of pre-clinical research can be greatly reduced, resources are saved, andthe research cycle can be shortened; and (4) nifedipine with working solutions is free of toxicity during animal experiments.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of the drug nifedipine. Background technique [0002] Tobacco dependence is a chronic, highly relapsing, addictive disease. The World Health Organization pointed out that there are currently 500 million smokers in the world, of which 360 million are smokers in my country, that is, one out of every four Chinese is a smoker. The number of deaths from smoking-related diseases worldwide is about 6 million every year, and the number of deaths from smoking-related diseases in my country exceeds 1 million, accounting for 16.4% of the deaths from various causes. Although smoking is very harmful, most smokers are unable or difficult to quit smoking successfully. From 2006 to the end of 2012, the central government allocated 60 billion yuan for smoking cessation action, but the effect is very little; it is the first time in the world to quit smoking successf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61P25/34
CPCA61K31/4422A61P25/34
Inventor 刘羽丹陈习华沙磊高迪张囡郑裕彤
Owner 中国医科大学
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