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Honokiol and application of magnolol in preparation of MCR-1 enzyme inhibitor

A technology of MCR-1 and honokiol, which is applied in the direction of resistance to vector-borne diseases, antibacterial drugs, active ingredients of hydroxyl compounds, etc., to achieve good therapeutic effects

Inactive Publication Date: 2019-11-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] After searching, there is no relevant report about honokiol and magnolol in the preparation of MCR-1 inhibitors

Method used

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  • Honokiol and application of magnolol in preparation of MCR-1 enzyme inhibitor
  • Honokiol and application of magnolol in preparation of MCR-1 enzyme inhibitor
  • Honokiol and application of magnolol in preparation of MCR-1 enzyme inhibitor

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Embodiment 1

[0016] Honokiol and magnolol as an MCR-1 enzyme inhibitor are used in any pharmaceutically acceptable carrier.

Embodiment 2

[0018] Honokiol and magnolol are used as MCR-1 enzyme inhibitors to prepare medicines for treating infectious diseases.

Embodiment 3

[0020] Honokiol and magnolol are used as MCR-1 enzyme inhibitors for the treatment of infectious diseases caused by bacteria, especially infections caused by MCR-1-positive Enterobacteriaceae.

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Abstract

The invention provides honokiol and application of magnolol in preparation of an MCR-1 enzyme inhibitor, provides honokiol and novel medical application of magnolol in preparation of an MCR-1 enzyme inhibitor and discloses honokiol and magnolo which can inhibit the activity of an MCR-1 enzyme and restore the sterilization activity of polymyxin to MCR-1 enteric bacilli. In an in-vivo experiment, the honokiol and magnolol are combined and applied to bacterial infection of the polymyxin for MCR-1 expression, particularly have a good treatment effect on infection caused by MCR-1 positive enteric bacilli and have a wide medical application range.

Description

technical field [0001] The invention discloses a new application of honokiol and magnolol, relates to the medical application of honokiol and magnolol in the preparation of MCR-1 enzyme inhibitors, and belongs to the technical field of medical pharmacy. Background technique [0002] The growing resistance of bacteria poses a serious threat to global public health, leading to the emergence of many cases of bacterial infections that are difficult to treat, among which infections caused by carbapenemase-producing Gram-negative enterobacteriaceae The condition is more serious, with the emergence of super drug-resistant bacteria, as well as the failure of treatment of drug-resistant bacteria and higher mortality, it has brought greater pressure to the treatment of nosocomial infections, especially the treatment of ICU infections. Colistin is the "last line of defense" for antibiotics to treat drug-resistant bacterial infections, but the discovery of MCR-1 has led to infections ca...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P31/04
CPCA61K31/05A61P31/04
Inventor 邓旭明郭岩王建锋周永林盛秋双卢娜
Owner JILIN UNIV
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