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Application of isoflavone compound Final-2 in preparing glucose transporter expression inhibitor of lung cancer cells

A final-2, glucose transport technology, used in the field of biomedicine to achieve the effects of blocking cyclic growth, inhibiting proliferation rate, and promoting apoptosis

Active Publication Date: 2019-10-25
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the treatment of lung cancer is improving with each passing day, the 5-year survival rate is only 14.1%, and 60% of patients die within 1 year of diagnosis
At present, there is no relevant report that the isoflavone compound Final-2 can be used in the treatment of lung cancer

Method used

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  • Application of isoflavone compound Final-2 in preparing glucose transporter expression inhibitor of lung cancer cells
  • Application of isoflavone compound Final-2 in preparing glucose transporter expression inhibitor of lung cancer cells
  • Application of isoflavone compound Final-2 in preparing glucose transporter expression inhibitor of lung cancer cells

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 isoflavone compound Final-2

[0049] The preparation process of isoflavone compound Final-2 is as follows figure 1 As shown, Final-2 is prepared through five steps of chemical reaction, which specifically includes the following steps:

[0050] 1. Preparation of intermediate 3

[0051]Genistein 2 (4.0 g, 29.6 mmol) was dissolved in 300 mL of methanol, and 3-methyl-2-butenal (14.4 mL, 148.0 mmol) and calcium hydroxide (4.4 g, 59.2 mmol) were added. The reaction solution was stirred at room temperature (18° C.) for 48 h and then concentrated. The resulting sample was dissolved in 300 mL of ethyl acetate and washed with 1M hydrochloric acid. The organic phase was separated, dried with anhydrous sodium sulfate and filtered with suction, and the filtrate was concentrated to obtain a crude product. The crude product was purified by silica gel column chromatography with petroleum ether and ethyl acetate to obtain 3.8 g of intermediate 3 as a y...

Embodiment 2

[0060] Example 2 Cell Functional Analysis Test

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Abstract

The invention belongs to the technical field of medicine, and particularly discloses an application of an isoflavone compound Final-2 in preparing a glucose transporter expression inhibitor of lung cancer cells, wherein the structure of the isoflavone compound is shown in a formula (I). According to a large number of experiments, the isoflavone compound Final-2 can specifically inhibit the expression of glucose transporter protein in lung cancer cells, can further inhibit the proliferation rate of lung cancer cells, block the periodic growth of lung cancer cells and promote the apoptosis of lung cancer cells, and thus the inhibitor can treat lung cancer and open up a new direction for lung cancer treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of the isoflavone compound Final-2 in the preparation of an inhibitor of glucose transporter expression in lung cancer cells. Background technique [0002] Primary bronchial lung cancer (abbreviated as lung cancer) is the malignant tumor with the highest incidence rate in recent years, and its incidence rate rises at the highest rate among all kinds of tumors. Lung cancer, which includes non-small cell lung cancer (NSCLC) and small cell lung cancer, is the second most common cancer diagnosed in men and women in the United States, accounting for 14 percent of all new cancers. In China, lung cancer is the most common cancer diagnosed in men and the most frequently diagnosed cancer in women, accounting for 23.03% and 16.2% of all new cases, respectively. Although the treatment methods for lung cancer are improving with each passing day, the 5-year survival rate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/352A61P35/00
Inventor 白卫滨蓝平陈子盛杨达城蒋鑫炜孙建霞田灵敏
Owner JINAN UNIVERSITY
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