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A blood streptococcin compound preparation for treating oral candidiasis and preparation method thereof

A technology for Candida albicans and streptococcus, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve extended drug effect period, high local drug concentration, increased activity and stability sexual effect

Active Publication Date: 2020-06-26
马晟利
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that streptococcin cannot accurately realize the drug effect on the affected part of the oral mucosa, the present invention provides a compound preparation of streptococcin for the treatment of oral candidiasis and its preparation method

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  • A blood streptococcin compound preparation for treating oral candidiasis and preparation method thereof

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Effect test

Embodiment 1

[0034] A blood streptococcin compound preparation for the treatment of oral candidiasis. The preparation is a powder injection for oral mucosa injection. The blood streptococin is evenly dispersed in the powder injection in the form of drug-loaded composite microspheres. The preparation includes the following qualities: Components: 3-10 parts of streptococcin, 1-3 parts of honeysuckle extract, 1-3 parts of Scrophulariaceae extract, 1-3 parts of Ophiopogon japonicus extract, 1-3 parts of menthol, sodium alginate 30-50 parts, chitosan 60-100 parts, Tween-808-10 parts and glucose 20-100 parts.

[0035]The particle size of the drug-loaded composite microspheres in this example is 20-50 μm, the drug-loaded amount of blood streptococcin in the drug-loaded composite microspheres is 2-9%, and the extracts of honeysuckle, Scrophulariaceae and Ophiopogon japonicus extract The drug loadings of menthol and menthol are both 0.5% to 3%. The oral mucosal injection powder is packaged in a ste...

Embodiment 2

[0037] A blood streptococcin compound preparation for the treatment of oral candidiasis. The preparation is a powder injection for oral mucosa injection. The blood streptococin is evenly dispersed in the powder injection in the form of drug-loaded composite microspheres. The preparation includes the following qualities: Components: 6 parts of streptococcin, 2 parts of honeysuckle extract, 2 parts of Scrophulariaceae extract, 2 parts of Ophiopogon japonicus extract, 2 parts of menthol, 40 parts of sodium alginate, 80 parts of chitosan, spit Wen-809 parts and glucose 80 parts.

[0038] The particle size of the drug-loaded composite microspheres in this example is 20-50 μm, the drug-loaded amount of streptococcin in the drug-loaded composite microspheres is 4%, and the honeysuckle extract, Scrophulariaceae extract, Ophiopogon japonicus extract and menthol The drug loading is 1%. The powder injection for oral mucosa injection in this example was packaged in a 15 mL sterile vial, ...

Embodiment 3

[0040] A preparation method of a blood streptococcin compound preparation for the treatment of oral candidiasis, comprising the steps of:

[0041] Step 1. Preparation of drug-loaded composite microspheres:

[0042] Weigh 30-50 parts of sodium alginate, prepare a sodium alginate solution with a certain mass concentration with deionized water, add 3-10 parts of sanocin into the sodium alginate solution, and disperse uniformly by ultrasonic to obtain drug-loaded seaweed Sodium acid solution for use;

[0043] Weigh 60-100 parts of chitosan, and use acetic acid as a solvent to prepare a chitosan solution with a certain mass concentration; 1-3 parts of honeysuckle extract, 1-3 parts of Scrophulariaceae extract, 1-3 parts of The extract and 1-3 parts of menthol are added to the chitosan solution, and ultrasonically dispersed to obtain a drug-loaded chitosan solution for use;

[0044] Add 8 to 10 parts of Tween-80 to the drug-loaded chitosan solution and stir evenly, under mechanica...

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Abstract

The invention relates to a streptocin compound preparation for treating candidiasis of the oral cavity and a preparation method of the preparation and belongs to the technical field of microorganism pharmacy. The problem is solved that streptocin cannot precisely achieve a medicine effect on the infected part of the mucous membrane of the oral cavity. The streptocin compound preparation for treating candidiasis of the oral cavity is a powder injection for injection to the mucous membrane of the oral cavity. An anti-fungal component streptocin is dispersed in the powder injection in a medicine-loading composite microsphere form, the activity and stability of the streptocin are improved, and the bioavailability of the preparation is improved. Flos lonicerae, radix scrophulariae, radix ophiopogonis and menthol can nourish yin, promote the secretion of saliva or body fluid and relieve the symptoms of the dry and scorching hot oval cavity of patients; sodium alga acid and chitosan are safe,free of toxicity, degradable and good in biocompatibility. According to the streptocin compound preparation, the mucous membrane of the injected part is subjected to injection and dosing, the medicine effect can be precisely achieved, the streptocin directly acts on candida albicans, the local concentration is high, and the effects of lowering adhesive power of the candida albicans and inhibitingand killing the candida albicans can be quickly achieved.

Description

technical field [0001] The invention belongs to the technical field of microbial pharmacy, and in particular relates to a blood streptococcin compound preparation for treating oral candidiasis albicans and a preparation method thereof. Background technique [0002] In recent years, due to the abuse of antibiotics, the frequent use of hormones and immunosuppressants, the incidence of Candida has increased year by year. Candida albicans is an opportunistic pathogenic bacterium that exists in the human oral environment. It is highly infectious and can cause a variety of oral mucosal diseases under certain conditions. The change of oral environment will cause the imbalance of flora in the oral cavity, and the key factor of periodontal disease is the imbalance of flora. The long-term persistence of human oral candidiasis indicates that the patient has local or systemic immunocompromise or loss. If antifungal drugs and other treatment measures are not given in time, it will lead ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/02A61P1/02A61P31/10A61K9/16A61K47/36A61K36/355A61K36/808A61K36/8968
CPCA61K9/0019A61K9/006A61K9/1652A61K9/167A61K9/1694A61K36/355A61K36/808A61K36/8968A61K38/02A61P1/02A61P31/10A61K2300/00
Inventor 马晟利
Owner 马晟利
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