Intestinal tract multi-modal movement integrated three-dimensional cavity intestinal organ-on-a-chip and method

Abstract

The present invention provides an intestinal tract multi-modal movement integrated three-dimensional cavity intestinal organ-on-a-chip and a method. The intestinal tract multi-modal movement integrated three-dimensional cavity intestinal organ-on-a-chip comprises a cavity porous thin film for culturing and differentiating intestinal epithelial cells, a supporting thin film is arranged on outside of the cavity porous thin film, the supporting thin film is connected with gas channels, the supporting thin film is driven to move through air inlet / exhaust of the gas channels so as to deform the cavity porous thin film to simulate actions of stressor contraction; a cavity with an accommodating area is arranged outside the cavity porous thin film, can provide a culture solution perfusion area forthe cavity porous thin film and forms a micro-mechanical environment with axial and circumferential shear stress; and a periphery of the cavity porous thin film is embedded with a plurality of closedmagnetic tapes, the closed magnetic tapes can generate magnetic fields along with electrification of a solenoid movably arranged outside the cavity, so that a radial contraction action is generated at corresponding positions of the cavity porous thin film.

Description

technical field [0001] The disclosure belongs to the fields of micro-electromechanical engineering and biomedical technology, and in particular relates to a three-dimensional cavity intestinal organ chip and method for integrating multi-modal movement of the intestinal tract. Background technique [0002] The statements in this section merely provide background information related to the present disclosure and do not necessarily constitute prior art. [0003] Currently, the screening of novel oral drugs for disease treatment mainly relies on animal models. Before new drugs enter the market, they need to be evaluated in animal models for efficacy and safety before further human clinical testing. Drug screening based on animal models is costly, time-consuming, and ethically controversial; more than 95% of the drugs that pass the test are not applicable to humans, and even have toxic side effects on humans. This result is related to the differences in enterocyte metabolic cap...

AI Technical Summary

Problems solved by technology

[0008] Only a single tonic contraction mode can be modeled, not the multimodal motility patterns of the gut (e.g., segmented radial contractions that play a major role in digestion / absorption function and peristaltic waves that propel digesta / drugs)

Images