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Preparation method of polysaccharide-zinc complex and zinc supplement

A compound and polysaccharide technology, applied in the field of zinc supplement preparation, can solve the problems of low absorption efficiency and availability, high molecular weight, low zinc supplement yield, etc., to optimize reaction time, improve yield, and solve absorption problems. Effects of low efficiency and utilization

Inactive Publication Date: 2019-10-15
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the common zinc supplements are mainly inorganic metal salts such as zinc gluconate, zinc lactate, zinc sulfate, etc. These zinc supplements have low yield and large molecular weight during preparation, and their absorption efficiency and utilization in the human body are very low.

Method used

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  • Preparation method of polysaccharide-zinc complex and zinc supplement
  • Preparation method of polysaccharide-zinc complex and zinc supplement
  • Preparation method of polysaccharide-zinc complex and zinc supplement

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preparation example Construction

[0049] Based on this, the present invention also proposes a method for preparing a polysaccharide zinc complex. The preparation method can be used to prepare Codonopsis pilosula polysaccharide-zinc complex and carboxymethyl tuckahoe polysaccharide with high zinc content, the codonopsis polysaccharide-zinc complex and the Carboxymethyl tuckahoe polysaccharide can be used to prepare the above zinc supplement. figure 1 Is an embodiment of the preparation method of the polysaccharide zinc complex of the present invention, combined figure 1 It can be known that the preparation method of the polysaccharide zinc complex includes the following steps:

[0050] Step S10, adding zinc acetate to the polysaccharide solution and adjusting the pH to 6-7 to obtain a mixed solution.

[0051] Step S20: Place the mixed solution at 60-70°C and react for 2 to 3 hours under water bath conditions to obtain a reaction solution.

[0052] Step S30: Dialyze the cooled reaction solution with flowing water, and ...

Embodiment 1

[0085] Take carboxymethyl tuckahoe polysaccharide and dissolve it in water at a material-to-liquid ratio of 3:500 to obtain a carboxymethyl tuckahoe polysaccharide solution; add zinc acetate to the carboxymethyl tuckahoe polysaccharide solution and adjust the pH to 6 to obtain a mixed solution; The mixed solution was reacted for 2 hours at 60°C in a water bath to obtain a reaction solution; the cooled reaction solution was placed in a dialysis bag with a molecular weight cut-off not greater than 3500, and dialyzed under running water for 24 hours to collect the retentate; Add 95% ethanol to the retentate until the volume concentration of ethanol in the retentate is 70-75%, let stand for 24 hours, and collect the precipitate; after the precipitate is dissolved in water, the precipitate is treated with alcohol, and the precipitate is taken at 30°C Under vacuum drying, polysaccharide zinc complex.

Embodiment 2

[0087] Take carboxymethyl tuckahoe polysaccharide and dissolve it in water according to a material-to-liquid ratio of 4:400 to obtain a carboxymethyl tuckahoe polysaccharide solution; add zinc acetate to the carboxymethyl tuckahoe polysaccharide solution and adjust the pH to 7 to obtain a mixed solution; The mixed solution was reacted at 70°C in a water bath for 3 hours to obtain a reaction solution; the cooled reaction solution was placed in a dialysis bag with a molecular weight cut-off not greater than 3500, and dialyzed under running water for 48 hours to collect the retentate; Add 93% ethanol to the retentate until the volume concentration of ethanol in the retentate is 70-75%, let stand for 30 hours, and collect the precipitate; after dissolving the precipitate in water, perform alcohol precipitation treatment and take the precipitate at 28°C Under vacuum drying, polysaccharide zinc complex.

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Abstract

The invention discloses a preparation method of a polysaccharide-zinc complex and a zinc supplement, and relates to the technical field of preparation of zinc supplements. The preparation method of the polysaccharide-zinc complex comprises the following steps: adding zinc acetate into a polysaccharide solution and adjusting pH to 6-7 to obtain a mixed solution; performing a reaction on the mixed solution for 2-3 hours under a temperature of 60-70 DEG C under a water-bath condition to obtain a reaction solution; and dialyzing the cooled reaction solution with flowing water, and separating and purifying a retentate to obtain the polysaccharide-zinc complex. A chelation reaction condition (temperature, pH, reaction time and the like) of polysaccharide molecules and zinc is optimized, so thatthe yield and the loading capacity of the zinc in the polysaccharide-zinc complex are greatly increased; in addition, the zinc supplement provided by the invention uses a codonopsis polysaccharide-zinc complex and a carboxymethyl pachyman-zinc complex as main effective components, so that the defects of low absorption efficiency and availability of the existing inorganic metal salt zinc supplementare overcome.

Description

Technical field [0001] The invention relates to the technical field of preparation of zinc supplements, in particular to a preparation method of a polysaccharide zinc complex and a zinc supplement. Background technique [0002] Trace elements are an important part of the nutrients required by the human body, and are an important factor in energy conversion and tissue composition in the digestion process of the living body. Among them, zinc is one of the trace elements necessary to maintain the normal physiological functions and biochemical metabolism of the body. Participates in various metabolisms of the body and is also an activator of enzymes in the human body. It plays an important role in maintaining the normal physiological functions of the human body, improving immunity, and promoting physical and intellectual development. [0003] At present, the common zinc supplements are mainly inorganic metal salts such as zinc gluconate, zinc lactate, zinc sulfate, etc. These zinc supp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00C08B37/02A61K33/30A61P3/02
CPCA61K33/30A61P3/02C08B37/0024C08B37/006
Inventor 张西锋袁帅舒畅李万芬鄢又玉
Owner WUHAN POLYTECHNIC UNIVERSITY
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