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Integrating method of multiple kinds of biological sequence notes

A biological sequence and sequence technology, applied in the field of integration of multi-type biological sequence annotations, can solve problems such as lack of annotation knowledge, achieve wide application value, improve utilization rate, and increase credibility

Active Publication Date: 2019-09-10
TSINGHUA UNIV
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  • Abstract
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Problems solved by technology

3. A large number of sequencing sequences are located in regions without prior functional annotations, lacking sufficient annotation knowledge

Method used

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  • Integrating method of multiple kinds of biological sequence notes
  • Integrating method of multiple kinds of biological sequence notes
  • Integrating method of multiple kinds of biological sequence notes

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Embodiment Construction

[0052] The following will describe the embodiment of the method for integrating multi-type biological sequence annotations according to the present invention with reference to the accompanying drawings. Those skilled in the art would recognize that the described embodiments can be modified in various ways or combinations thereof without departing from the spirit and scope of the invention. Accordingly, the drawings and description are illustrative in nature and not intended to limit the scope of the claims. Also, in this specification, the drawings are not drawn to scale, and like reference numerals denote like parts.

[0053] The integration method of multi-type biological sequence annotation in this embodiment, such as figure 1 As shown, it includes the following steps:

[0054] 1) Organize data

[0055] For the analysis of biological sequencing data results of different methods of the same organism, first analyze the sequencing method of the data and the sequencing depth...

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Abstract

The invention discloses an integrating method of multiple kinds of biological sequence notes. The method comprises the steps of extracting one kind of biological sequencing data from biological sequencing data as a main biological sequence set, and using the rest biological sequencing data as an auxiliary biological sequence set; establishing a sequence-gene association mapping set; acquiring a basic association area and an extended association area of the gene according to a gene transcription starting point; for the sequence of the main biological sequence set, performing traversal on the extended association area of the gene, and if the area with the sequence is intersected with the extended association area of a certain gene, establishing a sequence-gene association mapping between thegene and the sequence; applying reference data on a biological sequence noting result in the sequence-gene association mapping set and calculating the significance by means of ultra-geometric testingand binomial testing; respectively sequencing the notes which are obtained by the two methods, adding the sequence numbers of the same notes, performing sequencing again and using the sequencing result as a note result of multiple kinds of biological sequence data. The integrating method realizes noting of various characteristics and has application value in the medical field.

Description

technical field [0001] The present invention relates to the field of biotechnology, in particular, to an integration method for multiple types of biological sequence annotations. Background technique [0002] Gene sequencing is a new type of genetic testing technology that can analyze and determine the full sequence of genes from blood or saliva. With the development of biomedical technology, in the field of precision medicine, the technology of analyzing patients through sequencing and other methods to achieve precise treatment has also become more and more perfect. However, due to the lack of a unified standard for many sequencing methods on the market, their target sites and data distribution characteristics are very different, which also restricts the further development of the field of precise diagnosis. In response to this problem, it is an effective solution to try to integrate multiple types of data and annotate the functions and characteristics of various sequenced...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/10
CPCG16B30/10
Inventor 江瑞宋绍铭
Owner TSINGHUA UNIV
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