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Medicine for treating asthma and preparation method thereof

A kind of medicine and asthma technology, applied in the field of medicine for treating asthma and its preparation

Active Publication Date: 2019-08-20
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although pentacyclic triterpenoids have a wide range of pharmacological effects, there are no reports of using them for asthma treatment and prevention. Corosolic acid medicine for treating asthma and preparation method thereof

Method used

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  • Medicine for treating asthma and preparation method thereof
  • Medicine for treating asthma and preparation method thereof
  • Medicine for treating asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: A kind of tablet for treating asthma

[0037] 70 parts of suberone, 30 parts of corosolic acid, 400 parts of microcrystalline cellulose, 320 parts of powdered sugar, 80 parts of 10% starch slurry, 100 parts of crospovidone, appropriate amount of magnesium stearate, prepared according to the following method :

[0038] (1) Raw material preparation: take suberone and corosolic acid according to the formula quantity, pulverize through a 100-mesh sieve, and set aside;

[0039] (2) Making soft material: mixing subericone, corosolic acid, microcrystalline cellulose, powdered sugar, 10% starch slurry, and cross-linked povidone to make soft material, passing through a 14-mesh sieve for granulation and drying;

[0040] (3) Preparation: add magnesium stearate, mix uniformly and compress into tablets to obtain the tablet for treating asthma of the present invention.

Embodiment 2

[0041] Embodiment 2: A kind of sustained-release tablet for treating asthma

[0042] 70 parts of suberone, 30 parts of corosolic acid, 120 parts of sodium alginate, 80 parts of carboxymethyl cellulose, 90 parts of microcrystalline cellulose, 450 parts of powdered sugar, 80 parts of 80% ethanol, crospovidone 80 parts, an appropriate amount of magnesium stearate, prepared according to the following method:

[0043] (1) Raw material preparation: take suberone and corosolic acid according to the formula quantity, pulverize through a 100-mesh sieve, and set aside;

[0044] (2) Soft material: mix suberone and corosolic acid, sodium alginate, carboxymethyl cellulose, microcrystalline cellulose, powdered sugar, 80% ethanol and crospovidone to make soft material, 14-mesh sieve granulated and then dried;

[0045] (3) Preparation: add magnesium stearate, mix uniformly and compress into tablets to obtain the slow-release tablet for treating asthma of the present invention.

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Abstract

The invention relates to a medicine for treating asthma and a preparation method thereof. The medicine takes pentacyclic triterpenoid, particularly friedelin, corosolic acid or a mixture thereof and an optional second active ingredient as active ingredients for treating asthma, can obviously inhibit the attack of the asthma and inhibit the secretion of inflammatory factors, and has certain activity of inhibiting the contraction of tracheal smooth muscle, so that the medicine can be used for preventing and treating asthma.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a medicine for treating asthma and a preparation method thereof. Background technique [0002] Asthma (Asthma), also known as bronchial asthma, is an airway disease that is composed of eosinophils, mast cells, T lymphocytes, neutrophils, smooth muscle cells, airway epithelial cells and other cells and cell components. Chronic inflammatory disease. The clinical symptoms mainly include recurrent wheezing, shortness of breath, chest tightness, cough and other symptoms. According to a survey data in 2017, there are nearly 30 million asthma patients in my country, and the trend is increasing year by year, especially in adolescents and children, the most obvious increase in the prevalence of asthma. [0003] Asthma is mainly affected by genetic factors and environmental factors, but the specific pathogenesis is still unclear. The proposed pathological mechanism of asthma mainly i...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P11/06
CPCA61K31/56A61P11/06A61K2300/00
Inventor 刘晓冬张琦李强李芳巍李永生徐建忠
Owner MUDANJIANG MEDICAL UNIV
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