Barium colon transit test marker and preparation thereof

Abstract

The invention belongs to the technical field of in-vivo test preparations, and discloses a barium colon transit test marker and a preparation thereof. The method includes the steps that a medical-grade TPE tube without plasticizer dihexylphthalate is made into a short tube with the short diameter of 2 mm and the long diameter of 3.5 mm; after the short tube is filled with medical barium sulfate powder, the two ends are heat-sealed at an angle of 90 degrees; finally, the edges are trimmed to be smooth, and a special-shaped short-rod-like opaque marker is formed. Every ten grains are put into one capsule for a patient to swallow for examination; after the capsule is dissolved in the stomach, the short-rod-like marker participates in subsequent cavity digestive system transit together with food; observation is performed once every 24 hours in a colon transit test, reexamination radiography is performed 2-3 times according to the condition, and finally whether the patient suffers from intestinal canal motility disorder or not is judged. The barium colon transit test marker is convenient to make, safe and convenient, the marker quantity can be recorded more accurately, statistic analysis is performed, and an accurate diagnosis is made according to a radiopaque marker method.

Description

technical field [0001] The invention belongs to the technical field of preparations for in vivo tests, and in particular relates to a barium colonic transport test marker and a preparation method thereof. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] X-ray-opaque marker method (radiopaque marker's) colonic transport test, colonic transport test with markers, that is, oral administration of radiopaque markers, and determination of its retention and emptying rate in the body for 24 to 72 hours, has always been a slow diagnosis method. The preferred method for slow transit constipation (STC). The X-ray-opaque marker method for detecting gastrointestinal motility is simple, conforms to physiological conditions, and can quantitatively evaluate gastrointestinal emptying, which can provide a basis for guiding the clinical diagnosis and treatment of gastrointestinal motility disorders. [0004] In recent ...

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Problems solved by technology

[0006] (1) The barium method relies on the naked eye to estimate the residual barium in the body, and the marker method relies on specific data to calculate the residual markers in the body. The former observation and judgment are not accurate, and the barium dispersion method is not convenient for quantitative analysis, and diagnostic errors are more likely to occur

[0007] (2) The barium method swallows a large amount of barium, and the barium needs to be taken temporarily and mixed with water before swallowing. The marker method swallows a small amount of markers and swallows them in capsules. The former preparation steps are more cumbersome and swallowed directly. Taking barium will increase the patient's discomfort

[0008] (3) The medical barium sulfate used in the barium method is an insoluble heavy metal salt. Whether it will change the osmotic pressure of the intestinal crystals as a barium salt and affect the intestinal motility is currently unknown.

[0010] 1. There is no uniform standard for the preparation of colonic markers

[0011] 2. Many self-made markers in China are polyvinyl chloride (PVC) added with plasticizer di(2-ethyl)hexyl phthalate (DEHP). Its safety has always been controversial, and regulatory authorities have also issued Appropriate regulations and standards have been established to limit the use of DEHP

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