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Drug resistance judgment standard test method of mycoplasma gallisepticum to danofloxacin

A technology of mycoplasma gallisepticum and danofloxacin, which is applied in the direction of drug reference, can solve the problems of irrational clinical drug use, achieve protection and maintain effectiveness, improve stable development and economic benefits, and reduce drug resistance.

Active Publication Date: 2019-07-26
HUAZHONG AGRI UNIV
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Problems solved by technology

[0003] With the increasing resistance of Mycoplasma gallisepticum to antibiotics, more and more drugs can no longer be used in the clinical treatment of Mycoplasma gallisepticum. Therefore, it is a long way to go to control and slow down the emergence and spread of drug resistance through rigorous scientific means. Danofloxacin is widely used in the treatment of Mycoplasma gallisepticum in veterinary clinics due to its broad antibacterial spectrum and strong activity. Drug properties, in order to scientifically standardize the application of danofloxacin in the treatment of Mycoplasma gallisepticum disease, slow down the generation of its drug resistance, and help my country's veterinary workers to have rules to follow in the clinical process, the present invention proposes that Mycoplasma gallisepticum can treat Mycoplasma gallisepticum. Standard test method for danofloxacin resistance determination to address deficiencies in the prior art

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  • Drug resistance judgment standard test method of mycoplasma gallisepticum to danofloxacin
  • Drug resistance judgment standard test method of mycoplasma gallisepticum to danofloxacin
  • Drug resistance judgment standard test method of mycoplasma gallisepticum to danofloxacin

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Embodiment Construction

[0030]The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0031] according to figure 1 , 2 , 3, 4, 5, 6, 7, 8, 9, the present embodiment proposes Mycoplasma gallisepticum to danofloxacin drug resistance determination standard test method, comprising the following steps:

[0032] Step 1: Establish the wild-type cut-off value of danofloxacin against Mycoplasma gallisepticum, and use CO as the wild-type cut-off value WT According to the statement, 107 Mycoplasma gallisepticum strains were isolated and identified from c...

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Abstract

The invention discloses a drug resistance judgment standard test method of mycoplasma gallisepticum to danofloxacin, including the following steps: formulating a wild type critical value and a pharmacodynamic critical value of the danofloxacin to the mycoplasma gallisepticum, formulating a dosing scheme of the danofloxacin to the mycoplasma gallisepticum, formulating a clinical critical value of the danofloxacin to the mycoplasma gallisepticum, and obtaining a drug resistance judgment standard of the danofloxacin to the mycoplasma gallisepticum through a tree diagram which is made through a CLSI susceptibility breakpoint. With the adoption of the drug resistance judgment standard test method of mycoplasma gallisepticum to danofloxacin, the drug resistance judgment standard of the mycoplasma gallisepticum to the danofloxacin can be formulated; stable medication data support can be provided for scientific cultivation; clinical medication can be guided more scientifically; chronic respiratory diseases such as nasosinusitis, trachitis and air sacculitis of chickens can be effectively treated; reference is provided for clinical medication; drug resistance of mycoplasma gallisepticum todanofloxacin can be effectively relieved to a certain extent; and effectiveness of danofloxacin is protected and maintained.

Description

technical field [0001] The invention relates to the technical field of drug resistance determination, in particular to a standard test method for determining drug resistance of mycoplasma gallisepticum to danofloxacin. Background technique [0002] Mycoplasma gallisepticum is highly pathogenic to chickens and turkeys, and has the greatest impact on poultry farming. It mainly causes chronic respiratory diseases such as sinusitis, bronchitis and air sacculitis in chickens. [0003] With the increasing resistance of Mycoplasma gallisepticum to antibiotics, more and more drugs can no longer be used in the clinical treatment of Mycoplasma gallisepticum. Therefore, it is a long way to go to control and slow down the emergence and spread of drug resistance through rigorous scientific means. Danofloxacin is widely used in the treatment of Mycoplasma gallisepticum in veterinary clinics due to its broad antibacterial spectrum and strong activity. Drug properties, in order to scientific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40
CPCG16H70/40
Inventor 袁宗辉郝海红王淑歌黄安雄毕丁仁胡思顺王玉莲黄玲利王旭彭大鹏陈冬梅陶燕飞潘源虎谢书宇程古月瞿玮谷宇锋房诗薇戴新予黄啸郭金丽于耕涛
Owner HUAZHONG AGRI UNIV
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