A kind of processing method of the sodium phenylacetate deesterification liquid that penicillin g potassium salt crystallization mother liquor pyrolysis produces

A technology of sodium phenylacetate and a treatment method, applied in the field of treatment of sodium phenylacetate deesterification liquid, can solve problems such as many waste liquids and wastes, complicated overall procedures, high operating costs and the like

Active Publication Date: 2020-04-03
同舟纵横(厦门)流体技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment process of the sodium phenylacetate deesterification liquid in the above process requires a large amount of activated carbon and hydrogen peroxide, resulting in high operating costs, and the mother liquor after crystallization of sodium phenylacetate cannot be discharged directly because of its strong taste, but can only be incinerated, and has an overall process Disadvantages of complicated, waste liquid and waste

Method used

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  • A kind of processing method of the sodium phenylacetate deesterification liquid that penicillin g potassium salt crystallization mother liquor pyrolysis produces
  • A kind of processing method of the sodium phenylacetate deesterification liquid that penicillin g potassium salt crystallization mother liquor pyrolysis produces

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Extract the phenylacetic acid feed liquid from a factory with butyl acetate to obtain the extract, adjust the pH value of the extract to 9.5 with sodium hydroxide, and then carry out atmospheric distillation at 103-105°C to remove acetic acid butyl ester to obtain sodium phenylacetate deesterification solution; the concentration of butyl acetate in the gained sodium phenylacetate deesterification solution is ≤100ppm, sodium phenylacetate content 103.93mg / mL, light transmittance 30.4%, electrical conductivity 54700μs / cm, directly The temperature after deesterification is around 70°C;

[0059] Mix the sodium phenylacetate deesterification solution with activated carbon accounting for 0.5‰ of the mass of the sodium phenylacetate deesterification solution, and perform stirring and adsorption at a speed of 400 rpm and a temperature of 45°C. Press filter to obtain pretreated sodium phenylacetate deesterification liquid;

[0060] After the pretreated sodium phenylacetate dees...

Embodiment 2

[0067] Extract the phenylacetic acid feed liquid from a factory with butyl acetate to obtain the extract, adjust the pH value of the extract to 10.5 with sodium hydroxide, and then carry out atmospheric distillation at 105-108°C to remove acetic acid butyl ester to obtain sodium phenylacetate deesterification solution; the concentration of butyl acetate in the gained sodium phenylacetate deesterification solution is ≤50ppm, sodium phenylacetate content 200mg / mL, light transmittance 5%, the temperature after direct deesterification is at 80 around ℃;

[0068] Mix the sodium phenylacetate deesterification solution with activated carbon accounting for 1‰ of the mass of the sodium phenylacetate deesterification solution, and perform stirring and adsorption at a speed of 100 rpm and a temperature of 30°C. Press filter to obtain pretreated sodium phenylacetate deesterification liquid;

[0069] After the pretreated sodium phenylacetate deesterified solution is precision filtered (th...

Embodiment 3

[0076] The phenylacetic acid feed liquid of a certain factory is adjusted to pH 10 with sodium hydroxide, and the sodium phenylacetate feed liquid is subjected to atmospheric distillation at 103-108°C to remove butyl acetate to obtain sodium phenylacetate deesterification liquid; the obtained phenylacetic acid The concentration of butyl acetate in the sodium deesterification solution is ≤100ppm, the content of sodium phenylacetate is 110mg / mL, the light transmittance is 30%, and the temperature after direct deesterification is about 70°C;

[0077] Mix the sodium phenylacetate deesterification solution with activated carbon accounting for 1‰ of the mass of the sodium phenylacetate deesterification solution, and perform stirring and adsorption at a speed of 100 rpm and a temperature of 45°C. Press filter to obtain pretreated sodium phenylacetate deesterification liquid;

[0078] After the pretreated sodium phenylacetate deesterified solution is precision filtered (the filter hol...

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Abstract

The invention provides a disposal method of sodium phenylacetate deesterification liquid generated by cracking a penicillin G potassium salt crystallization mother liquor and belongs to the technicalfield of pharmaceutical wastewater disposal. The method comprises the steps of mixing a sodium phenylacetate deesterification liquid and active carbon, removing a penicillin degradation product, and conducting filtering to obtain a predisposed sodium phenylacetate deesterification liquid; carrying out primary dialysis on the predisposed sodium phenylacetate deesterification liquid to obtain a primary dialysate and a primary concentrated liquid, wherein the cut-off molecular weight of a dialysis membrane used for the primary dialysis is 6,000-10,000 Da; performing secondary dialysis on the primary dialysate to obtain a secondary dialysate and a secondary concentrated liquid, wherein the cut-off molecular weight of a dialysis membrane used for secondary dialysis is 1,000-4,000 Da; concentrating the secondary dialysate and returning the secondary dialysate to a penicillin fermentation working section. According to the disposal method, there is no need to add hydrogen peroxide or conduct crystallization and crystallization remelting, the amount of generated waste liquid is small, and the energy consumption is low.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical wastewater treatment, in particular to a method for treating sodium phenylacetate deesterified liquid produced by cracking penicillin G potassium salt crystallization mother liquor. Background technique [0002] At present, the penicillin G potassium salt crystallization mother liquor treatment process is: add penicillin lyase, penicillin G potassium salt is cracked into 6-aminopenicillanic acid (i.e. 6-APA) and phenylacetic acid, after phenylacetic acid is extracted by butyl acetate, Use sodium hydroxide to adjust the pH value to 9-10.5, convert phenylacetic acid into sodium phenylacetate, and then distill under normal pressure at 100-110°C to obtain sodium phenylacetate deesterification liquid, and then use 10% hydrogen peroxide and 3‰ activated carbon to decolorize , and then return to the penicillin fermentation section after evaporative crystallization and crystal remelting. The treat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F9/02C02F103/34
CPCC02F1/281C02F1/44C02F2103/343
Inventor 张勇朱振煌林雄水肖启瑞严滨叶茜
Owner 同舟纵横(厦门)流体技术有限公司
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