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Bioreconstructed material for treating skeletal defects

A skeletal defect and biological technology, applied in medical science, prosthesis, etc., can solve the problem that the patient's bones cannot be restored to the original structure, etc.

Inactive Publication Date: 2019-05-28
孔祥圣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no matter what the situation is, it is impossible to restore the patient's bone structure to its original structure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 1.0 g of commercially available hydrophobic polysaccharide, slowly pour it into 100 ml of collagen solution with a concentration of 5.0%, and pour it while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type III collagen dissolved in 0.2mol / L phosphoric acid. After stirring evenly, stir for 1 hour at an ambient temperature of 23°C. Weigh 20.0 g of calcium chloride, pour it into the above components and stir for 2 hours, and adjust the pH value to 7 with 1.0 mol / L sodium hydroxide solution. The obtained composite material is placed in a rectangular tank of less than 60 meshes for cross-linking and dehydration molding. The mass ratio of polysaccharide to collagen is 1:5; the mass ratio of collagen:calcium chloride is 1:4.

Embodiment 2

[0013] Take 3.0 g of commercially available hydrophobic polysaccharides, slowly pour into 100 ml of collagen solution with a concentration of 5.0%, and pour while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type III collagen dissolved in 0.5mol / L phosphoric acid. After stirring evenly, stir for 1 hour at an ambient temperature of 10°C. Weigh 20.0 g of calcium chloride, pour it into the above components and stir for 2 hours, and adjust the pH value to 7 with 1.0 mol / L sodium hydroxide solution. The obtained composite material is placed in a rectangular tank of less than 60 meshes for cross-linking and dehydration molding. The mass ratio of polysaccharide to collagen is 3:5; the mass ratio of collagen:calcium chloride is 1:4.

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Abstract

The invention discloses a bioreconstructed material for treating skeletal defects and belongs to the field of medical biomaterials. The invention mainly aims at solving the problem of restoring original structures of skeletons after skull, frontal plan bone, nasal bone and phalanx are damaged in the current clinic. By establishing a balance point between biological reconstruction and material degradation-absorption speed, postoperative collapse is prevented; in addition, the aim of skeleton reconstruction is realized by providing an osteoprogenitor cell growth matrix and a crawling channel fora receptor. A material prepared by the method is prepared by the following steps: carrying out structural reconstruction on hydrophobic polysaccharide and collagen, remodulating mineralized calcium phosphorus ions by collagen, forming hydroxyapatite composite, and finally cross-linking, dehydrating and molding. The bioreconstructed material is a stable, hard and porous material with good biocompatibility. The bioreconstructed material is beneficial to reconstructing the skeleton of the damaged skull, frontal plan bone, nasal bone and phalanx.

Description

technical field [0001] The invention relates to a bioreconstructable material for treating bone defects. It belongs to the field of medical biomaterials. Background technique [0002] At present, the injury rate of skull, frontal bone, nasal bone and phalanx caused by accidents such as car accidents and high-altitude falls in the world is getting higher and higher. Such skeletal defects also occur due to genetic causes. At present, large wounds are mostly treated with titanium mesh or silica gel, while small wounds are left untreated. However, no matter what the situation is, it is impossible to restore the patient's bone to its original structure. To a large extent, it affects the normal life of the patient and increases the psychological pressure of the patient. [0003] In view of this, it is particularly important to develop a bioreconstructable material that is hard on the outside, porous on the inside, and has a certain load-bearing capacity. And because the struc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56
Inventor 孔祥圣
Owner 孔祥圣
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