Preparation method of gel for preventing anastomotic fistulae after colorectal surgery

An anastomotic fistula and post-operative technology, applied in the field of medical gel, can solve the problems of fast curing speed of medical gel, contamination by pathogenic organisms, unfavorable healing, etc., and achieve the effects of accelerating the coagulation speed, increasing the blasting strength, and shortening the operation time.

Active Publication Date: 2019-05-24
HAINAN JIANKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (1) α-cyanoacrylic medical glue cures quickly, which is not conducive to adjusting the thickness of the colorectal anastomosis, and the polymerization heat during curing is easy to burn the surface of the colorectal anastomosis, which is not conducive to healing
α-cyanoacrylic medical glue becomes solid after curing, and it is easy to break and leak when the colorectum is peristaltic, and it will cause frictional damage to surrounding tissues
Toxic substances are produced during degradation, which is not conducive to human absorption
[0007] (2) Fibrin glue such as Tisseel, Encore glue, Beixiu, FloSeal, etc. are products from blood, and there is a risk of contamination by pathogenic organisms
The use of small molecule aldehyde crosslinking agents also has certain toxicity

Method used

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  • Preparation method of gel for preventing anastomotic fistulae after colorectal surgery
  • Preparation method of gel for preventing anastomotic fistulae after colorectal surgery
  • Preparation method of gel for preventing anastomotic fistulae after colorectal surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for preparing a gel for preventing anastomotic leakage after colorectal surgery, comprising the following steps:

[0046] Step 1, using the component A1 buffer solution to dissolve the corresponding component A2 powder to obtain the component A solution;

[0047]Step 2, using the component B1 buffer solution to dissolve the corresponding component B2 powder to obtain the component B solution;

[0048] Step 3. After the dissolution is completed, use two syringes to absorb the prepared components A and B solutions respectively, and install the two syringes on the double injection rack, connect the two syringes to the compound injection seat, and connect the nozzle To the compound injection seat, spray to form a gel;

[0049] The powder of component A2 is four-arm-polyethylene glycol amine hydrochloride; the powder of component B2 is four-arm-polyethylene glycol cysteine ​​amide.

[0050] The compound injection seat is a Y-joint compound injection seat.

[0051...

Embodiment 2

[0054] A method for preparing a gel for preventing anastomotic leakage after colorectal surgery, comprising the following steps:

[0055] Step 1, using the component A1 buffer solution to dissolve the corresponding component A2 powder to obtain the component A solution;

[0056] Step 2, using the component B1 buffer solution to dissolve the corresponding component B2 powder to obtain the component B solution;

[0057] Step 3. After the dissolution is completed, use two syringes to absorb the prepared components A and B solutions respectively, and install the two syringes on the double injection rack, connect the two syringes to the compound injection seat, and connect the nozzle To the compound injection seat, spray to form a gel;

[0058] The powder of component A2 is four-arm-polyethylene glycol amine hydrochloride; the powder of component B2 is four-arm-polyethylene glycol cysteine ​​amide.

[0059] The compound injection seat is a Y-joint compound injection seat.

[006...

Embodiment 3

[0063] A method for preparing a gel for preventing anastomotic leakage after colorectal surgery, comprising the following steps:

[0064] Step 1, using the component A1 buffer solution to dissolve the corresponding component A2 powder to obtain the component A solution;

[0065] Step 2, using the component B1 buffer solution to dissolve the corresponding component B2 powder to obtain the component B solution;

[0066] Step 3. After the dissolution is completed, use two syringes to absorb the prepared components A and B solutions respectively, and install the two syringes on the double injection rack, connect the two syringes to the compound injection seat, and connect the nozzle To the compound injection seat, spray to form a gel;

[0067] The powder of component A2 is four-arm-polyethylene glycol amine hydrochloride; the powder of component B2 is four-arm-polyethylene glycol cysteine ​​amide.

[0068] The compound injection seat described is a Y-joint compound injection sea...

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Abstract

The invention discloses a preparation method of gel for preventing anastomotic fistulae after colorectal surgery. The preparation method includes the following steps: dissolving 4 arm-polyoxamide hydrochloride in a hydrochloric acid solution to obtain a component A solution; dissolving 4 arm-polyethylene glycol cysteine amide in a mixed solution of sodium hydroxide and sodium hydrogen phosphate toobtain a component B solution; after dissolution, respectively sucking the prepared component A and B solutions by two syringes, mounting the two syringes on a duplex injection frame, sleeving the syringes and a nozzle with a combined injection seat, and performing spraying to form the gel. The hemostatic sealant ( the gel for preventing the anastomotic fistulae after the colorectal surgery) canbe used for preventing the anastomotic fistulae after the colorectal surgery, is beneficial to accumulation of nutrients and growth factors, and promotes healing of anastomotic stomas; the product canbe degraded and absorbed, and can prevent adhesion while sealing intestinal fistulae.

Description

technical field [0001] The invention relates to the technical field of medical gel, in particular to a preparation method of gel for preventing anastomotic leakage after colorectal surgery. Background technique [0002] Anastomotic leakage after colorectal resection usually occurs within 4-9 days after surgery. Anastomotic leakage after anterior resection of rectal cancer is related to many factors, which can be divided into surgical and individual factors. Surgical factors include surgical skills, anastomotic location, operation time, intraoperative blood loss, local blood supply of anastomosis, and anastomotic tension , surgical site infection, intraoperative blood transfusion, and bowel preparation; individual factors included gender, smoking, obesity, diabetes, chronic disease, ASA stage, and preoperative neoadjuvant therapy. Besides surgical skill and quality, anastomotic location was considered the most important factor and was the only one consistently reported in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00
Inventor 杨顶建吴垚赵军
Owner HAINAN JIANKE PHARMA
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