Glucosamine and application of derivative of glucosamine as antiviral drug

Abstract

The invention provides a glucosamine compound shown as the general formula I and application of pharmaceutically acceptable salt or solvate in preparation of the antiviral drug. The compound has excellent antiviral effect, particularly the broad spectrum property of the antiviral effect is remarkable, and the glucosamine can be used for preparing the antiviral drug. (See the general formula in thedescription.).

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of glucosamine and its derivatives in the preparation of antiviral drugs and a preparation method thereof. Background technique [0002] N-acetyl-D-glucosamine is the smallest unit of chitin and the basic unit of many important polysaccharides in biological cells. It is an amino monosaccharide formed by replacing the OH group on the 2-position of the glucose molecule with an acetamido group. Chemically, it can be easily synthesized by acetylating the amino group at the 2-position in the glucosamine molecule, and the natural N-acetyl-D-glucosamine can be hydrolyzed by biotechnology through the shell of crustaceans (such as crabs and shrimps) and then processed obtained by refinement. The substance has many important physiological functions in living organisms. The main application functions are as follows: [0003] 1. Anti-cancer, anti-tumor and immune regula...

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Problems solved by technology

[0006] Although N-acetyl-glucosamine has a variety of physiological effects, its application in the antiviral field has not been reported. The inventors of the present invention found that N-acetyl-glucosamine and its derivatives It has obvious inhibitory effect on a variety of viruses, and the safety of N-acetylglucosamine has been verified in various aspects, so its development as an antiviral drug has broad prospects

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