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A Bacillus coagulans producing fibrinolytic enzyme and the preparation method of fibrinolytic enzyme and live bacteria tablet

A technology of Bacillus coagulans and plasmin, which is applied in the field of microorganisms and enzyme engineering, can solve the problems of restricting the development of functional foods with plasmin and less research on the production of plasmin by lactic acid bacteria, and achieves good drug sensitivity and preparation method. Simple, high-viability effect

Active Publication Date: 2020-11-06
SICHUAN AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these bacteria are strains that cannot be directly used in food, so the development of functional food with plasmin is limited.
[0004] At present, there are few studies on the production of plasmin by lactic acid bacteria

Method used

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  • A Bacillus coagulans producing fibrinolytic enzyme and the preparation method of fibrinolytic enzyme and live bacteria tablet
  • A Bacillus coagulans producing fibrinolytic enzyme and the preparation method of fibrinolytic enzyme and live bacteria tablet
  • A Bacillus coagulans producing fibrinolytic enzyme and the preparation method of fibrinolytic enzyme and live bacteria tablet

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Embodiment Construction

[0032] The present invention is described in detail by the following examples, it is necessary to point out that the following examples are only used to further illustrate the present invention, and can not be interpreted as limiting the scope of the present invention, those skilled in the art according to the content of the above invention Some non-essential improvements and adjustments still belong to the protection scope of the present invention.

[0033] In this patent, unless otherwise specified, "strain HQ-1" and "HQ-1" both refer to Bacillus coagulans (CGMCC No. 16058).

[0034] 1 Materials and methods

[0035] 1.1 Test material

[0036] Samples: 489 traditional fermented foods collected from various places in Sichuan, including fermented soybean paste, kimchi water, northeast fermented soybean paste, and Fujian fermented shrimp paste.

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Abstract

The invention provides bacillus coagulans HQ-1 capable of generating plasmin. The bacillus coagulans HQ-1 is preserved in China general microbiological culture collection center, wherein the preservation number is CGMCC No.16058, and the classification designation is bacillus coagulans (Bacillus coagulans). The invention further provides a method for preparing the plasmin and viable bacteria tablets by using the bacillus coagulans HQ-1. The prepared bacillus coagulans has favorable drug sensitivity, bacterial inhibition and resistance to acid base environment. The obtained bacillus coagulans is high in plasmin activity, and can achieve 383.1U / mL. The obtained viable bacteria tablets are simple in preparation method, and high in viable bacteria rate, and have favorable practical applicationprospects.

Description

technical field [0001] The invention belongs to the technical field of microbes and enzyme engineering, and in particular relates to a strain of bacillus coagulans producing plasmin and a method for preparing plasmin and live bacteria tablets. Background technique [0002] Thrombotic disease (TD) is currently one of the diseases that endanger human health and has the highest mortality rate. Thrombolytic therapy is currently one of the most commonly used and most effective treatments for such diseases. However, the current clinically used thrombolytic drugs are far from meeting the market demand, and they also have disadvantages such as low specificity for decomposing fibrin, short half-life in vivo, easy to cause bleeding, and expensive. Therefore, countries all over the world are devoting themselves to the development of effective, non-toxic and inexpensive new thrombolytic drugs, and the search for plasmin from natural sources has also become a research hotspot. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20C12N9/68A61K35/742A61P7/02C12R1/07
Inventor 胡欣洁周倩朱琦琦何维赵俊梅余冬梅韩国全刘书亮刘爱平
Owner SICHUAN AGRI UNIV
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