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Multi-channel microfluidic coagulation detection chip with five-layer structure

A technology for detecting chips and microfluidics, which is applied in measurement devices, laboratory utensils, laboratory containers, etc., can solve the problem of large chip size, etc., and achieves the effects of high speed, reduced production cost, and reasonable design.

Pending Publication Date: 2019-04-26
NANJING LANSION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The multi-channel rapid detection microfluidic detection chip is a three-layer chip, and the size of the chip body is about 8-10cm*2.4-2.8cm, so the size of the chip is too large

Method used

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  • Multi-channel microfluidic coagulation detection chip with five-layer structure
  • Multi-channel microfluidic coagulation detection chip with five-layer structure
  • Multi-channel microfluidic coagulation detection chip with five-layer structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: as Figure 1~5 As shown, the multi-channel microfluidic blood coagulation detection chip with a five-layer structure includes a chip body, and the chip body sequentially includes a first layer chip 1, a second layer chip 2, a third layer chip 3, and a second layer chip from top to bottom. The four-layer chip 4 and the fifth-layer chip 5, the first-layer chip 1, the second-layer chip 2, the third-layer chip 3, the fourth-layer chip 4 and the fifth-layer chip 5 cooperate to define a closed micro-flow channel and a plurality of mutually independent detection chambers 9, the first layer chip 1 is provided with a sample loading hole 8, and the sample loading hole 8 communicates with the detection chamber 9 through the micro flow channel 6; The chip body also includes electrodes, and each of the detection chambers 9 is uniformly provided with the electrodes; the second layer of chips 2 and the fourth layer of chips 4 are provided with the micro flow channels 6 a...

Embodiment 2

[0044] Embodiment 2: as Figure 6-10As shown, the difference from Example 1 is that the second working electrode 1102 and the second reference electrode 1002 are arranged on the front side of the fifth-layer chip 5; specifically, the multi-channel with five-layer structure The microfluidic blood coagulation detection chip includes a chip body, and the chip body sequentially includes a first layer chip 1, a second layer chip 2, a third layer chip 3, a fourth layer chip 4 and a fifth layer chip 5 from top to bottom, The first layer chip 1, the second layer chip 2, the third layer chip 3, the fourth layer chip 4 and the fifth layer chip 5 cooperate to define a closed micro flow channel and a plurality of mutually independent detection chambers 9, The first-layer chip 1 is provided with a sample loading hole 8, and the sample loading hole 8 communicates with the detection chamber 9 through the micro flow channel 6; the chip body also includes electrodes, each of the detection cham...

Embodiment 3

[0045]Embodiment 3: The multi-channel microfluidic blood coagulation detection chip with a five-layer structure includes a chip body, and the chip body sequentially includes a first layer chip 1, a second layer chip 2, a third layer chip 3, The fourth layer of chips 4 and the fifth layer of chips 5, the first layer of chips 1, the second layer of chips 2, the third layer of chips 3, the fourth layer of chips 4 and the fifth layer of chips 5 cooperate to define a closed micro flow channel and a plurality of mutually independent detection chambers 9, the first layer chip 1 is provided with a sample loading hole 8, and the sample loading hole 8 communicates with the detection chamber 9 through the micro flow channel 6; The chip body also includes electrodes, and each of the detection chambers 9 is uniformly provided with the electrodes; the second layer chip 2 and the fourth layer chip 4 are provided with the micro flow channel 6 and the detection chamber 9; the microfluidic chan...

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Abstract

The invention discloses a multi-channel microfluidic coagulation detection chip with a five-layer structure. The chip comprises a chip body, the chip body comprises a first layer chip, a second layerchip, a third layer chip, a fourth layer chip and a fifth layer chip from top to bottom in sequence, the first layer chip, the second layer chip, the third layer chip, the fourth layer chip and the fifth layer chip cooperate to define a closed microfluidic channel and a plurality of independent detection chambers, a feeding hole is formed in the first layer chip, and the feeding hole is communicated with the detection chambers through the microfluidic channel; the chip body further includes electrodes, and each of the detection chambers is provided with the electrodes in correspondence. A five-layer chip design can multiply the number of the detection chambers so that more coagulation indexes can be detected at one time, and the detection efficiency is improved. The multi-channel microfluidic coagulation detection chip with the five-layer structure is reasonable in design and simple and compact in structure.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a multi-channel microfluid coagulation detection chip with a five-layer structure. Background technique [0002] Microfluidics is a technology applied across various disciplines including engineering, physics, chemistry, microtechnology and biotechnology. Microfluidics involves the study of small volumes of fluids and how such small quantities of fluids are manipulated, controlled and used in various microfluidic systems and devices, such as microfluidic chips. For example: microfluidic biochips (referred to as "lab-on-a-chip") are used in the field of molecular biology to integrate assay operations for purposes such as analyzing enzymes and DNA, detecting biochemical toxins and pathogens, diagnosing diseases, and the like. [0003] Microfluidic chip (microfluidic chip) is currently a hot field in the development of Miniaturized Total Analysis Systems. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416B01L3/00
CPCG01N27/416B01L3/5025B01L3/5027B01L3/502723B01L3/502715B01L2300/0645B01L2300/0816B01L2300/0887B01L2200/0684G01N33/4905B01L2200/027B01L2200/0647B01L2200/141B01L2200/16B01L2300/0663B01L2300/0864
Inventor 许行尚杰弗瑞·陈
Owner NANJING LANSION BIOTECH CO LTD
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