Self-calibrating glucose continuous monitoring system and preparation method thereof

Abstract

The invention discloses a self-calibrating glucose continuous monitoring system, which comprises a film substrate and the following components arranged on the film substrate: an intercellular fluid extraction electrode and an intercellular fluid extraction auxiliary electrode for extracting intercellular fluid in skin; a glucose sensor working electrode and a glucose sensor reference electrode/counter electrode for measuring the glucose concentration in the extracted intercellular fluid; a sodium ion sensor working electrode and a differential sodium ion sensor reference electrode for measuring the sodium ion concentration in the extracted intercellular fluid; a sweat sodium ion sensor working electrode and a differential sodium ion sensor reference electrode for measuring sodium ion concentration in sweat; and a Nafion semi-permeable membrane layer for enhancing the affinity of the system with skin. The invention further discloses a monitoring system preparation method. The system adopts a differential structure, which can eliminate the influence of natural sweat on the measurement results, and thus a measurement result is more accurate and reliable.

Description

technical field [0001] The invention relates to the technical field of glucose monitoring, in particular to a self-calibrating glucose continuous monitoring system and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, changes in diet structure and lifestyle, population aging and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The importance of continuous blood glucose monitoring in the diagnosis and treatment of diabetes has been increasingly recognized by people. If painless and uninterrupted continuous blood glucose monitoring can be performed on patients and more closely data on continuous changes in blood glucose concentration can be provided, it will be able to reflect the "full picture" of the patient's blood glucose, measure those neglected blood glucose information, and reveal the hidden The state of blood sugar, to find those repeated episodes of hypoglycemi...

AI Technical Summary

Problems solved by technology

Although this method can achieve transdermal extraction of subcutaneous intercellular fluid and continuous monitoring of glucose concentration, due to individual differences, different people and the skin of the same person at different locations have different characteristics, and the properties of the skin will vary with time. gradually changes over time, which will lead to different volumes of intercellular fluid extracted and affect the measurement accuracy

Moreover, factors such as natural sweating will also affect the measurement accuracy.

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