Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of screening method of Sihuang anti-acne compound formula

A screening method and compound technology, which is applied in the fields of medical formula, medical preparations containing active ingredients, chemical property prediction, etc., can solve problems such as the lack of clear understanding of the anti-acne efficacy of traditional Chinese medicine compound, and achieve the effect of good technical support

Active Publication Date: 2021-11-26
ANHUI UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] From the analysis of the mechanism of acne, it can be found that traditional Chinese medicinal materials need to play a certain role in each stage of acne in order to achieve a better anti-acne effect. There is no specific research on the effect of the anti-acne effect of the compound formula, so people do not have a clear understanding of the anti-acne effect of the traditional Chinese medicine compound used

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of screening method of Sihuang anti-acne compound formula
  • A kind of screening method of Sihuang anti-acne compound formula
  • A kind of screening method of Sihuang anti-acne compound formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] Reagents used: Coptis chinensis, Treats, Scutellaria baicalensis, Rhubarb, purchased from Hefei People's Yuan Pharmacy; p-dimethylaminobenzaldehyde, reduced coenzyme II (NADPH, 95%), testosterone (98%), Aladdin reagent (Shanghai) Co., Ltd.; Tris (Tris, 99.9% biotech grade), Coomassie brilliant blue G-250 (AR, no protease), 10mg / mL bovine serum albumin standard solution (analytical standard), Shanghai McLean Biochemical Technology Co., Ltd.; Beef Extract, Beijing Auboxing Biotechnology Co., Ltd.; Sodium Chloride, Peptone, Sinopharm Chemical Reagent Co., Ltd.; Aplite (5mg / tablet, active ingredient content), Jiangsu Lianhuan Pharmaceutical Co., Ltd. Company; 5α-reductase extract, laboratory extraction, the concentration is 0.29mg / mL.

[0022] A screening method for Sihuang acne-removing compound, comprising the following steps:

[0023] (1) Preparation of Chinese herbal water extract of Sihuang: Four Chinese herbal medicines, including Coptis chinensis, Cortex Phellodendr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a screening method of Sihuang Acne Removing Compound. On the basis of Sanhuang Fu, an ancient anti-acne prescription, Chinese herbal extracts of Coptis chinensis, Cortex Phellodendron, Scutellaria baicalensis, and rhubarb were selected as effective ingredients for anti-acne. The scavenging ability of the compound on DPPH•, the ability to inhibit the activity of hyaluronidase and 5α-reductase, and the inhibitory effect on Staphylococcus aureus are scientifically analyzed and compared from four aspects to determine the best compound ratio , providing a scientific basis for the effect of the addition amount of the four kinds of Chinese herbal medicines on the anti-acne efficacy of the compound formula. Since the source of Sihuang is natural, it is in line with the concept of safe skin care for modern people. Compared with acne medicines and cosmetics on the market, it has more advantages in application. The invention provides better technical support for the ancient prescriptions and the research and development of the four-yellow compound anti-acne products.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine combinations, and in particular relates to a screening method for Sihuang and acne-removing compound. Background technique [0002] Acne problem has become one of the biggest troubles for young people. Traditional Chinese medicine believes that the pathogenesis of acne can be summarized as lung heat, blood heat, damp heat, wind heat, external attack of wind evil, yin deficiency and blood stasis, yin and yang imbalance, qi and blood disharmony, Gastrointestinal heat accumulation, Chong and Ren disorders, etc., are mostly fever. Sanhuangfu, Sanhuangsan, and Sanhuang ointment are the most commonly used in ancient acne-removing prescriptions. Rhizoma Coptidis, Treats, and Scutellaria belong to heat-clearing medicines, while rhubarb is a laxative. [0003] Modern scientific research has shown that the pathogenesis of acne is related to excessive androgen levels in the body. The ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G16C20/30A61K36/756A61P17/10
CPCA61K36/539A61K36/708A61K36/718A61K36/756A61P17/10A61K2300/00
Inventor 王雪梅陈紫薇潘佩瑶李茜媛肖伟莉金芊芊汪叶笛徐诗童左晶晶
Owner ANHUI UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products