Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of valproic acid in preparation of anti-bacterial and anti-inflammatory drugs

An antibacterial and anti-inflammatory technology, valproic acid, applied in the preparation of antibacterial and anti-inflammatory drugs, new uses of valproic acid, new drug applications, can solve the problems that have not yet been reported on the application of valproic acid anti-bacterial and anti-inflammatory drugs

Inactive Publication Date: 2019-03-29
GENERAL HOSPITAL OF PLA +1
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, according to the prior art, valproic acid is mainly used in the preparation of drugs such as anti-tumor, treatment of epilepsy and bipolar disorder, and prevention of migraine, and there is no report on the application of valproic acid in the preparation of antibacterial and anti-inflammatory drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of valproic acid in preparation of anti-bacterial and anti-inflammatory drugs
  • Application of valproic acid in preparation of anti-bacterial and anti-inflammatory drugs
  • Application of valproic acid in preparation of anti-bacterial and anti-inflammatory drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The following examples are provided to further illustrate but not limit the present invention.

[0026] 1. Materials and methods:

[0027] 1.1 Bacteria and cells

[0028] Fusobacterium nucleatum (F. nucleatum, Fn, ATCC 25586) was obtained from the frozen bacterial strain bank of the Key Laboratory of Oral Tissue Regeneration in Shandong Province.

[0029] Gingival fibroblasts (HGF): isolated from 6 volunteer patients aged 18-30 who underwent extraction of impacted teeth.

[0030] 1.2 Reagents

[0031] Defibrinated sheep blood (Haibo Bio Company, Qingdao, Shandong, China), PBS (Soleibao, Beijing, China), hemin-vitamin K1 (Haibo Bio Company, Qingdao, Shandong, China), brain Heart infusion blood culture medium (Suolaibao, Beijing, China), BHI liquid medium (Suolaibao, Beijing, China), type I collagenase (Suolaibao, Beijing, China), DispaseII dispase (Invitrogen, Carlsbad, CA, USA), intracellular reactive oxygen species detection kit (Bebo, Shanghai), valproic acid (Sel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of valproic acid in preparation of anti-bacterial and anti-inflammatory drugs. By performing RNA-Seq transcriptome analysis on human cells infected by bacteria, onbasis of co-expression pathway and drug genome enrichment analysis methods, a list of candidate drugs with anti-bacterial and anti-inflammatory effects are obtained; and then, several marketed drugs with the anti-bacterial and anti-inflammatory effects, as well as the valproic acid of which the anti-bacterial and anti-inflammatory effects have not been found before, are found out. Thus, the valproic acid can be used for preparing anti-bacterial and anti-inflammatory drugs.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to a new application of valproic acid, specifically its application in the preparation of antibacterial and anti-inflammatory drugs, and belongs to the field of biomedicine. Background technique [0002] Valproic acid (valproic acid), a selective inhibitor of HDAC, also inhibits the proteasomal degradation of HDAC2, is used to treat epilepsy and bipolar disorder, and to prevent migraine. [0003] Valproic acid directly inhibits histone deacetylases through different pathways, with an IC50 of 0.4mM for HDAC1. In cultured cells, valproic acid acts like the histone deacetylase inhibitor trichostatin, causing deacetylation of histones. Valproic acid also activates transcription from different exogenous and endogenous promoters. In vertebrate embryos, valproic acid and trichostatin have very similar teratogenic effects without activating transcription (see Phiel, Christopher J., et al."...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/19A61K45/06A61P31/04A61P29/00
CPCA61K31/19A61K45/06A61P29/00A61P31/04A61K2300/00
Inventor 何昆仑贾志龙冯强康文燕王卫东石金龙赵晓静贾倩刘春蕾
Owner GENERAL HOSPITAL OF PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com