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Composition and combination of photostabilising BMDBM sunscreens

A composition and photostabilization technology, applied in the direction of drug combination, skin care preparations, active ingredients of heterocyclic compounds, etc., can solve problems such as cross allergy and contact eczema, and achieve good absorption response effect

Pending Publication Date: 2019-03-29
PIERRE FABRE DERMO COSMETIQUE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, octocrylene has the drawback of being a powerful allergen causing contact eczema in children and cross-sensitivity with ketoprofen

Method used

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  • Composition and combination of photostabilising BMDBM sunscreens
  • Composition and combination of photostabilising BMDBM sunscreens
  • Composition and combination of photostabilising BMDBM sunscreens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0099] In Vitro Method for Assessing Overall UV and UVA Photostability

[0100] A) material

[0101] -UV spectrophotometer:

[0102] The spectrophotometer measures the spectral transmittance through the panel with and without a layer of sunscreen composition on the surface.

[0103] The spectrophotometer should allow measurements between 290nm and 400nm. In order to reduce the variability between measurement readings and to compensate for the lack of uniformity of the product layer, it is recommended that the reading area of ​​the site is at least 0.5cm 2 .

[0104] The spectrophotometer used for these measurements was UV-1000S or 2000S.

[0105] -plate:

[0106] A panel is the material on which the sunscreen composition is applied. The material must be UV transparent, non-fluorescent, photostable and inert with respect to the compound of the composition being tested. For this solution, polymethylmethacrylate (PMMA) sheets proved ideal.

[0107] -UV source:

[0108]...

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Abstract

The present invention relates to composition and combination of photostabilising BMDBM sunscreens, especially, the present invention concerns a combination comprising butyl methoxy dibenzoyl methane (BMDBM), bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT) and methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) through light stability and composition of an excipient received by drugs or cosmetics, wherein (i), the BEMT / BMDBM ratio by mass is greater than or equal to 1 and is preferably greater than or equal to 1.5, (ii), the content of the BMDBM in the total weight of the composition is in a range between 1-5; and (iii) the amount of the MBBT in the total weight of the composition is in a range between 3-7, and the composition does not includes octocrylene, PABA or ethyl and hexyl methoxycinnamate esters.

Description

[0001] This application is a Chinese patent application with the application number 201380007218.3, the application date is January 30, 2013, and the invention title is "composition and combination of sunscreen agents for light-stabilized butylmethoxydibenzoylmethane (BMDBM)" divisional application. technical field [0002] The present invention relates to a combination of photostable sunscreens for butylmethoxydibenzoylmethane (BMDBM). Background technique [0003] Protection against UVA (320-400nm) must substantially limit the damage associated with prolonged exposure that can lead to changes in the skin, acceleration of photoaging, loss of skin elasticity, and the like. [0004] First, review the nomenclature and abbreviations of the main filters involved in the scope of the present invention: [0005] - Butylmethoxydibenzoylmethane (BMDBM) = Avobenzone = CAS registration number: 70356-09-1, the filter is under the DSM trademark Sale, [0006] -2,4-bis[4-(2-ethylhexyl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/35A61K8/37A61K8/29A61K31/53A61Q17/04A61P17/16A61K31/12A61K31/192A61K31/4192
CPCA61K8/35A61K8/496A61Q17/04A61K31/4192A61K31/53A61K2800/30A61K31/12A61K8/4966A61P17/00A61P17/16A61K2300/00A61K8/29A61K8/37A61K8/40A61K8/42A61K8/49
Inventor V·佩里耶H·德罗米尼
Owner PIERRE FABRE DERMO COSMETIQUE CORP
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