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Biomedical material for treating gastric ulcer and preparation method thereof

A biomedical material, gastric ulcer technology, applied in the field of medicine, can solve problems such as unclear treatment mechanism, adverse reactions, and large side effects

Active Publication Date: 2021-04-06
WENZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing gastric ulcer treatment method is mainly chemical drug therapy, the main problem is that chemical drugs have relatively large side effects on the stomach, there are adverse reactions, and the treatment cycle is long; traditional Chinese medicine combinations have many therapeutic methods for gastric ulcer, but Chinese medicine There are many varieties of preparations, the therapeutic effect varies greatly, and the therapeutic mechanism is unclear

Method used

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  • Biomedical material for treating gastric ulcer and preparation method thereof
  • Biomedical material for treating gastric ulcer and preparation method thereof
  • Biomedical material for treating gastric ulcer and preparation method thereof

Examples

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preparation example Construction

[0024] The invention provides a method for preparing a biomedical material for treating gastric ulcer, the preparation steps comprising:

[0025] S1. Loading calcium carbonate on the outer surface of the pollen wall to form a first sample.

[0026] Among them, it should be noted that the pollen wall mentioned in the present invention is a natural pollen exine with a cavity structure, and the main component of the pollen exine is sporopollenin, which has strong corrosion resistance and acid and alkali resistance. Refers to. The pollen wall has multiple transport channels communicating with the cavity. The outer surface of the outer wall of pollen has protrusions, such as semicircular, thorn-like or irregular protrusions, that is, the outer surface is rough, which is convenient for loading calcium carbonate and polydopamine in the later stage. At the same time, after gastric ulcer occurs, The surface structure of the gastric mucosa is damaged, and a large number of inflammator...

Embodiment 1

[0056] Extraction of sunflower spore powder exine (SEC)

[0057] 1.1 Extraction of defatted sunflower pollen

[0058] Take 20g of dried sunflower pollen in a round bottom flask, add 200ml of ether, stir overnight at room temperature at 600rpm, remove the ether by suction filtration, wash with ether three times, dry at 60°C, and store at room temperature.

[0059] 1.2 Extraction of sunflower spore powder exine (SEC)

[0060] Take 10g of defatted sunflower pollen, grind it, add 150mL of 85% phosphoric acid, react at 70°C and 600rpm for 10h, wash with 200mL hot water three times, 100mL hot acetone twice, 100mL 2M hot HCl twice, 200mL hot water 3 times, washed twice with 100mL hot acetone and twice with 100mL hot ethanol to obtain yellow solid particles, dried at 60°C to obtain brown SEC, the scanning electron microscope picture of SEC is shown in figure 1 .

[0061] Depend on figure 1 It can be seen that the surface of SEC is covered with thorn-like structures. In nature, tho...

Embodiment 2

[0063] A preparation method for a biomedical material for treating gastric ulcer, which is prepared by the following method:

[0064] 1. Preparation of the first sample

[0065] Get the SEC that 2mg embodiment 1 makes, it is 0.1M CaCl in 0.2mL concentration 2 Disperse evenly, and then use a syringe pump to inject 0.2mL with a concentration of 0.05M Na 2 CO 3 , react at 150rpm, 4°C, and the reaction conditions of injection speed 0.5mL / min for 1min. After the reaction, centrifuge at 12000rpm for 4min to remove the supernatant, then wash once with 0.2mL deionized water, collect the solid and lyophilize it. Brown's first sample.

[0066] figure 2 It is the scanning electron microscope picture of the first sample. It can be observed that there is a layer of calcium carbonate adhered on the surface of SEC. Calcium carbonate can neutralize gastric acid, relieve gastric ulcer, maintain bFGF activity, and achieve the therapeutic effect of protein drugs.

[0067] 2. Preparation of...

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Abstract

The invention relates to a biomedical material for treating gastric ulcer and a preparation method thereof, relating to the field of medicine. The preparation method is obtained by coating the surface of the first sample with polydopamine after the outer surface of the pollen wall is loaded with calcium carbonate to form the first sample, and the operation is simple and reliable. The biomedical material for treating gastric ulcer provided by the invention can exert the effects of anti-oxidation, anti-inflammation, neutralization of gastric acid and inhibition of ulcer enlargement at the site of gastric ulcer wound formation.

Description

technical field [0001] The invention relates to the field of medicine, and in particular to a biomedical material for treating gastric ulcer and a preparation method thereof. Background technique [0002] Gastric ulcer is a common digestive tract disease, which mainly refers to the tissue damage beyond the muscularis mucosa caused by the gastric mucosa being digested by the gastric digestive juice itself. The cause of gastric ulcer is related to the stress state of the body, the stimulation of physical and chemical factors, and the infection of some pathogenic bacteria. [0003] The existing gastric ulcer treatment method is mainly chemical drug therapy, the main problem is that chemical drugs have relatively large side effects on the stomach, there are adverse reactions, and the treatment cycle is long; traditional Chinese medicine combinations have many therapeutic methods for gastric ulcer, but Chinese medicine There are many kinds of preparations, the therapeutic effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/46A61K45/06A61K33/10A61K31/785A61P1/04
CPCA61K9/0065A61K9/1664A61K9/167A61K9/1676A61K31/785A61K33/10A61K45/06A61P1/04A61K2300/00
Inventor 何华成吴疆杨耀陈艳欣宣暄李校堃
Owner WENZHOU UNIV
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