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Application of combination of hydrogen-rich aqueous solution and amifostine to resistance of radiation damage

A technology of radiation damage and aqueous solution, applied in the field of radiation protection, can solve problems such as hypersensitivity, acute hypotension, oral ineffectiveness, etc., and achieve good anti-radiation damage and excellent anti-radiation damage effects

Pending Publication Date: 2019-02-26
CHINA INST FOR RADIATION PROTECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented product contains two different solutions: one with high levels of hydrogen gas (H2) while another without it. These H2 gases help protect against harm from ionizing rays during exposure. When these compositions are mixed together they form an effective treatment for cancer patients who have been exposed to radiations or chemotherapy treatments.

Problems solved by technology

The technical problem addressed in this patented text relates to finding better ways to prevent exposing radioactive materials (RNAs) from being affected due to their potential negative impact upon humans like cancer risk. Current methods involve adding chemical agents called hormones into food products during production processes which may cause health concerns over longer periods. Therefore there needs to find alternative solutions without these drawbacks while maintaining good results against other factors affecting cellular functions.

Method used

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  • Application of combination of hydrogen-rich aqueous solution and amifostine to resistance of radiation damage
  • Application of combination of hydrogen-rich aqueous solution and amifostine to resistance of radiation damage
  • Application of combination of hydrogen-rich aqueous solution and amifostine to resistance of radiation damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation that is rich in hydrogen aqueous solution

[0018] Add purified water (prepared by the NW20VF ultrapure water system produced by Hong Kong Likang Biomedical Technology Co., Ltd.) into the portable H-rich 2 In the water machine (Shanghai Luying Environmental Protection Technology Development Co., Ltd., HS-71), the hydrogen-rich aqueous solution was prepared, and the hydrogen-rich aqueous solution prepared was immediately used in the research of the following examples (ammoniaphosphorus can be further dissolved therein as required) Ting to prepare the aqueous solution rich in hydrogen and the aqueous solution composition of amifostine, i.e. joint action composition), to ensure rich H 2 The hydrogen concentration in the water is greater than 0.5mmol / L (the hydrogen concentration in the water is measured with the ENH-1000 portable dissolved hydrogen analyzer from Japan TRUSTLEX Company).

Embodiment 2

[0019] Example 2: Animal Radiation Exposure

[0020] 48 SPF-grade ICR mice, male, weighing 13-15 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army [production license number: SCXK (army) 2012-0004, certificate number: 0015608]. The purchased animals were kept in a normal environment [license number: SYXK (Jin) 2008-0004].

[0021] After 9 days of quarantine, the animals were randomly divided into control group, simple irradiation group, amifostine group, hydrogen-rich water group and combined action group according to body weight. The control group consisted of 8 animals, and each of the other groups consisted of 10 animals.

[0022] (1) Control group: the animals did not receive radiation exposure, and were given purified water by gavage with a volume of 20ml / kg;

[0023] (2) Simple irradiation group: the animals received whole-body radiation exposure, and purified water was given by gav...

Embodiment 3

[0028] Embodiment 3: Animal indicator detection

[0029] 1. Instruments and reagents required for testing

[0030] MEK-6318K three-classification automatic blood cell counter (Nippon Kohden); SELECTRA-E automatic biochemical analyzer (Rittal, Holland); VANOX microscope (OLYMPUS); BD202 electronic balance (Mettler-Toledo); BS124S electronic balance (Sartorius).

[0031] Diluent for blood cell analyzer (Shanghai Optoelectronic Medical Electronic Instrument Co., Ltd., batch number: 1305-0283); biochemical reagents (all produced by Shanghai Fosun Changzheng Medical Science Co., Ltd.).

[0032] 2. Detection indicators and methods

[0033] The following indicators were tested before and after radiation exposure.

[0034] (1) 30-day survival rate

[0035] The survival of animals in each group was observed within 30 days after irradiation, and the 30-day survival rate, average survival days and protection index were calculated.

[0036]

[0037] In the formula, a, a' are the a...

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Abstract

The invention relates to application of a combination of a hydrogen-rich aqueous solution and amifostine to resistance of radiation damage, belonging to the technical field of radiation protection. Acomposition of the hydrogen-rich aqueous solution and an aqueous amifostine solution in the invention can better resist radiation damage.

Description

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Claims

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Application Information

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Owner CHINA INST FOR RADIATION PROTECTION
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