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Compound bromelain ointment and preparation method thereof

A technology of bromelain and its manufacturing method, which is applied in the field of compound bromelain ointment and its manufacture, can solve the problems of complex surgery, not ideal, and inability to prevent and control the infection of the wound during the scab removal period, so as to prevent and control the infection Effect

Inactive Publication Date: 2019-02-22
浙江华缔药业集团有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method either causes great pain to the patient, or requires relatively complicated operation, and is not very ideal; the medicine for treating deep burns on the market takes a long time to remove the scab, and cannot prevent and control the infection situation of the wound surface during the scab removal stage. The present invention needs to solve this problem. The problem;

Method used

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  • Compound bromelain ointment and preparation method thereof
  • Compound bromelain ointment and preparation method thereof
  • Compound bromelain ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: 30% bromelain, 5% lysozyme, 0.1% vitamin A, substrate 47.2%, water 17.7%;

Embodiment 2

[0060] Embodiment 2: 35% bromelain, 5% lysozyme, 0.1% vitamin A, matrix 43.6%, water 16.4%;

Embodiment 3

[0061] Example 3: 40% bromelain, 5% lysozyme, 0.1% vitamin A, 40.0% matrix, 14.9% water.

[0062] After the guinea pigs were modeled and the thick scab was formed, the ointment was applied to the wound surface, bandaged and fixed, twice a day.

[0063] (4) Results

[0064] Scab removal time: The results showed that the 30%, 35% and 40% experimental groups could remove the scabs at 17.8±9.1 hours, 17.1±6.9 hours and 16.3±7.4 hours respectively, significantly earlier than the negative control group, matrix group and MEBO .

[0065] group

Scab removal time h

negative control

306.2±29.3

Matrix control

251.6±31.6

30% experimental group

17.8±9.1

35% of the experimental group

17.1±6.9

40% experimental group

16.3±7.4

moist burn ointment

233.7±26.4

[0066] Result analysis, adopting the formula of the present invention generally has a short scab removal time, and the shortest time is the 40% experimental gr...

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PUM

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Abstract

The invention discloses compound bromelain ointment and a preparation method thereof. A formula of the compound bromelain ointment is prepared from the following components in percentage by mass: 30 to 40 percent of bromelain, 3 to 7 percent of lysozyme, 0.1 percent of vitamin A, 20 to 50 percent of a matrix and 12.9 to 46.9 percent of water. According to the formula disclosed by the invention, natural decrustation time is quickened through the bromelain, specific sterilization mechanism and broad-spectrum sterilization ability can be increased through the lysozyme, the infection situation during a wound decrustation period can be effectively prevented and controlled, and the vitamin A is beneficial for matural collagen synthesis, epithelialisation and vascularization, so that the compoundbromelain ointment can be used for decrustation of deep II-degree and III-degree burn wounds and has the function of controlling wound infection and inflammation, and the time for skin grafting of patients suffering from deep II-degree and III-degree burn can be quickened. The preparation method is designed according to physicochemical characteristics of the formula, and the drug effect can be expressed to the maximum.

Description

technical field [0001] The invention relates to the field of external medicine for deep burns, in particular to a compound bromelain ointment and a manufacturing method thereof. Background technique [0002] Clinically, I degree and superficial II degree burns are called superficial burns, and deep II degree and III degree burns are classified as deep burns. The patented invention is aimed at deep burns. A layer of pale, yellowish white, burnt yellow or black necrotic tissue will form on the deep burn wound, which is the eschar. If no infection occurs, deep second-degree burns and small-area deep third-degree burn wounds will heal under the scab after 17-20 days. The eschar of obviously infected deep second-degree wounds and third-degree burns begins to separate from healthy tissues and descarpate in 2-3 weeks, and the descarpation time is longer. At this time, a large amount of necrotic tissue liquefies, and as the time of scab removal prolongs, the infection will aggrav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K9/06A61P17/02A61K31/07A61K38/47
CPCA61K9/0014A61K9/06A61K31/07A61K38/47A61K38/4873A61P17/02A61K2300/00
Inventor 周正兵唐自军张治国戴彬彬周洁
Owner 浙江华缔药业集团有限责任公司
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