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Systems and methods for calibrating and correcting speckle contrast flowmeters

A contrast, laser speckle technology, applied in CCTV systems, scattering characteristics measurement, liquid/fluid solid measurement, etc., can solve problems such as quantification of flow and speckle contrast

Active Publication Date: 2021-02-05
柯惠股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the main disadvantage of LSI is that it is very susceptible to multiple noise sources
Since LSI relies on the standard deviation between pixels, noise from random and / or systematic sources such as shot noise or dark sensor noise can affect the speckle contrast and thus the quantification of the flow

Method used

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  • Systems and methods for calibrating and correcting speckle contrast flowmeters
  • Systems and methods for calibrating and correcting speckle contrast flowmeters
  • Systems and methods for calibrating and correcting speckle contrast flowmeters

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Embodiment Construction

[0028] The systems, devices and methods disclosed herein may include component arrangements including a light source 100, a photodetector 200 (i.e., a photosensitive detector, such as an image sensor), memory, and one or more processors operable to are connected to each other to interrogate the sample 300. In many embodiments, a sample may be a physiological sample, such as a tissue region of a subject, related to which physiological information is to be determined. A subject can be a living animal, such as a human. Component devices may be standard devices for use in new configurations, methods and / or systems, or they may be devices that are specially designed or adapted for implementation in the systems and methods disclosed herein. The light source 100 may be configured to emit at least partially coherent light. The light source 100 can be a laser, such as a diode laser. In some embodiments, light source 100 is a VCSEL laser. Light detector 200 may include one or more l...

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Abstract

Disclosed herein are systems, methods, and apparatus for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion properties, such as flow rates. The calibration step stores to memory calibration data, which may include a set of measurements and / or noise estimates from a sample with known particle properties, including effects on contrast caused by undesired signals unrelated to unknown particle motion properties . Calibration data can be accessed and used to correct empirical measurements of contrast and / or to interpolate values ​​for unknown particle motion properties. The system may include a light source, light detector, processor, and memory that may be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device can be used, for example, to measure blood flow, cardiac output and heart rate, and can be used to amplify pulsatile signals.

Description

[0001] cross reference [0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 324,903, filed April 20, 2016, which is hereby incorporated by reference in its entirety for all purposes. Any and all related applications to which this provisional application is based or by way of priority from this provisional application are hereby incorporated by reference in their entirety. Background technique [0003] The present disclosure relates to devices, systems and methods for calibrating and correcting flow measurements made using laser speckle imaging (LSI). LSI is an optical technique that uses interferometric information to determine the rate of motion within a sample. LSI is typically performed with a coherent illumination source and an image sensor, where the light interrogates the sample and randomly interferes with the image sensor, producing a marked "speckle" pattern. The patterns are then analyzed in space and / or time to det...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H04N7/18G06F17/18G01F1/7086
CPCG01F1/7086G01F1/74G01F1/712G01B9/02094G01N21/47G01N2021/479A61B5/0261
Inventor 杨毅泰勒·拜沃特斯·莱斯肖恩·迈克尔·怀特
Owner 柯惠股份公司
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