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Device and method for ex vivo lung ventilation using varying external pressure

A technology for lung ventilation and pressure, which is applied in the field of lung ventilation devices, and can solve problems that have not yet been disclosed.

Active Publication Date: 2022-06-07
TEVOSOL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these authors have not disclosed any specific details of effective strategies for ex vivo ventilation of the lungs using positive and negative pressures

Method used

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  • Device and method for ex vivo lung ventilation using varying external pressure
  • Device and method for ex vivo lung ventilation using varying external pressure
  • Device and method for ex vivo lung ventilation using varying external pressure

Examples

Experimental program
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Effect test

Embodiment

[0139] Example I

[0140] Exemplary apparatus and methods described in this disclosure (eg, as Figure 3-8 shown in) was used for EVLP and combined negative and positive pressure ventilation (NPV / PPV) in a series of experiments in pig lungs. For each experiment, a pair of lungs were rapidly excised from 40-50 kg pigs after appropriate euthanasia and exsanguination. Mount the lungs in a sealable container in this device. An endotracheal tube is attached to the trachea of ​​the lung. The vasculature of the lungs is connected to the perfusion system and perfusion begins. The perfusate includes a decellularized albumin solution, a mixture of whole blood and an albumin solution, or a mixture of packed red blood cells (pRBC) and an albumin solution. The composition of the albumin solution is listed in Table 1.

[0141] Table 1: Composition of albumin solution for lung perfusion

[0142] ingredients mmol / L g / 4L glucose 10 7.20 Sodium chloride 117 27....

Embodiment IV

[0167] Example IV (control)

[0168] Figure 22 An exemplary control device 400 for negative pressure ventilation is illustrated, tested with three pig lungs (N=3). Device 400 is used to apply negative pressure within organ chamber 410 . In this example, the device 400 is not used to deliver positive airway pressure in the lung airways.

[0169] In the test, the donor lung 450 was placed in a hard-shell sealed container 410 in a device 400 . Container 410 is partially filled with saline liquid 480 . Lungs 450 float on top of flexible plastic membrane 482, and liquid 480 floats them.

[0170] Tracheobronchial tree 452 of lung 450 is connected to catheter 432 by endotracheal catheter 444. Catheter 462 connects perfusion device 460 to pulmonary artery 454 of lung 450. Catheter 464 connects perfusion device 460 to pulmonary vein 456 of lung 450 .

[0171] The container 410 is sealed from the atmosphere by a lid 412 . Conduit 432 extends through cap 412 through port 414 . ...

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Abstract

The present disclosure relates to a method of ventilating a resected lung. Ventilation gas is applied to the airways of the lungs and creates a vacuum around the lungs. The vacuum level of the vacuum is varied between a lower level and a higher level to induce lung breathing while adjusting the pressure of ventilation gas supplied to the airways to maintain a positive airway pressure in the lung airways. The vacuum level of this vacuum is periodically changed between said two vacuum levels. This level may be maintained substantially constant over a period of time, with either or both of said lower or said higher level being adjusted during ventilation. The lungs may be placed in a sealed chamber in which a vacuum is created around the lungs.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to and the benefit of US Provisional Patent Application No. 62 / 343,076, filed on May 30, 2016, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure relates generally to devices and methods for ventilation of lungs, and more particularly to devices and methods for ventilation of resected lungs by varying external pressures. Background technique [0004] In order to use excised donor lungs for transplantation, the excised lungs may require ex vivo perfusion and ventilation to restore or maintain their function, or to assess or evaluate their potential for transplantation, prior to transplantation. quality or suitability. [0005] For ex vivo ventilation of excised lungs, a common conventional mechanical ventilation technique utilizes positive pressure applied to the tracheobronchial tree. This creates a pressure gradient betwe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
CPCA01N1/02A01N1/0247A01N1/0289A01N1/0242A61M16/0009A61M16/00A61M16/0057A61M16/1005A61M2205/3344A01N1/021
Inventor D·弗里德
Owner TEVOSOL INC
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