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A kind of preparation method of water-based disposable antibacterial emulsion with zero skin penetration

A technology for penetrating water and skin, applied in the field of hand sanitizer, can solve problems such as skin dehydration and keratinization, and achieve the effect of increasing penetration resistance and improving biological safety.

Active Publication Date: 2021-06-18
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process provided by this patent has certain advantages in the field of preparation of leave-on gel, but because it uses 39-42% ethanol in the preparation process, the use of high-concentration ethanol can easily lead to dehydration and keratinization of the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of preparation method of water-based no-wash antibacterial emulsion with zero skin penetration:

[0022] (1) Weigh 18 g of sulfonated nanocellulose emulsion, add 1.35 times the weight of deionized water to the emulsion, and undergo ultrasonic treatment at a frequency of 60KHZ to obtain a uniform test solution.

[0023] (2) Weigh triclosan according to the mass ratio of 63.5:1, and weigh ethanol according to the mass ratio of triclosan and organic solvent as 1:1.5, and put it in a constant temperature water bath ultrasonic instrument (ultrasonic frequency 40KHZ, water bath temperature 32°C) Ultrasound for 10 minutes to fully mix the bacteriostatic reagent solution.

[0024] (3) Use a homogenizer to pre-shear the sulfonated nanocellulose for 40 minutes at a lower rotational speed of 2800r / min, increase the rotational speed to 8300r / min and add the bacteriostatic agent dropwise to the above-mentioned sulfonated nanocellulose emulsion. solution (dropping speed 5mg / m...

Embodiment 2

[0027] A kind of preparation method of water-based no-wash antibacterial emulsion with zero skin penetration:

[0028] (1) Weigh 19 g of sulfonated nanocellulose emulsion, add 1.35 times the weight of deionized water to the emulsion, and undergo ultrasonic treatment at a frequency of 70KHZ to obtain a uniform test solution.

[0029] (2) Take benzalkonium bromide by mass ratio of 63.5:1, be 1:1.5 by weighing edible glycerin by the mass ratio of benzalkonium bromide and organic solvent, and in constant temperature water bath ultrasonic instrument (ultrasonic frequency 50KHZ, water bath temperature 30 °C) for 15 minutes of ultrasonication to fully mix the bacteriostatic agent test solution.

[0030] (3) Use a homogenizer to pre-shear the sulfonated nanocellulose for 35 minutes at a lower rotational speed of 3000r / min, increase the rotational speed to 8500r / min and add the bacteriostatic agent dropwise to the above-mentioned sulfonated nanocellulose emulsion. solution (dropping s...

Embodiment 3

[0033] A kind of preparation method of water-based no-wash antibacterial emulsion with zero skin penetration:

[0034] (1) Weigh 20 g of sulfonated nanocellulose emulsion, add 1.35 times the weight of deionized water to the emulsion, and undergo ultrasonic treatment at a frequency of 80KHZ to obtain a uniform test solution.

[0035] (2) Weigh triclosan according to the mass ratio of 63.5:1, and weigh ethanol according to the mass ratio of triclosan and organic solvent as 1:1.5, and put it in a constant temperature water bath ultrasonic instrument (ultrasonic frequency 60KHZ, water bath temperature 35°C) Ultrasound for 15 minutes to fully mix the bacteriostatic reagent solution.

[0036] (3) Use a homogenizer to pre-shear the sulfonated nanocellulose for 30 minutes at a lower rotational speed of 3100r / min, increase the rotational speed to 9000r / min and add the bacteriostatic agent dropwise to the above-mentioned sulfonated nanocellulose emulsion. solution (dropping speed 6mg / m...

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PUM

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Abstract

The invention relates to a method for preparing a water-based no-clean antibacterial emulsion with zero skin penetration. The prepared sulfonated nanocellulose emulsion is pre-sheared by a homogenizer, and the rotation speed is increased, and the emulsion is added drop by drop to the above-mentioned sulfonated nanocellulose emulsion. Add the bacteriostatic agent test solution dropwise. After the bacteriostatic agent test solution is added dropwise, increase the rotating speed to 12000-13000r / min, and add stearic acid 1-2.5% sequentially according to the mass ratio to the total weight of the bacteriostatic hand sanitizer. Lemon butter 0.8-1.25%, glycerin 1.9-2.0%, after all components are added, continue to cut for 20-30min to prepare zero-penetration water-based leave-on antibacterial emulsion. The present invention takes the lead in using pure bio-based sulfonated nano-cellulose to load the bactericide, so that it changes from a free state to a composite state, increases its penetration resistance, and reduces the amount of penetration into the skin. At the same time, due to the unique conjunctival ability of sulfonated nanocellulose, it can fundamentally block the capillary penetration path of fungicides into the skin, thereby achieving zero penetration of fungicides into the skin and improving the biosafety of disposable antibacterial hand sanitizers sex.

Description

technical field [0001] The invention belongs to the field of hand sanitizers, and relates to a no-wash hand sanitizer, in particular to a preparation method of a water-based no-wash antibacterial emulsion with zero skin penetration. Background technique [0002] Since 100% of the bacteriostatic agent remains on the surface of the skin in the water-based disposable antibacterial hand sanitizer, its permeability to the inside of the skin directly affects the safety effect of its use. The bacteriostatic agents of conventional water-based hand sanitizers are in a molecular free state in the formula composition, which can easily penetrate into the skin and cause certain physiological toxicity to the body. [0003] CN104287979A discloses a silver-loaded mesoporous silicon-containing disposable antibacterial hand sanitizer and a preparation method thereof, comprising the following steps: adding a skin care agent to an alcohol substance, heating and stirring to dissolve to form an a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/41A61K8/34A61Q19/10A61Q17/00
CPCA61K8/347A61K8/416A61K8/731A61K2800/82A61Q17/005A61Q19/10
Inventor 孙波张民王维君周庆礼吴涛司传领刘锐倪永浩
Owner TIANJIN UNIV OF SCI & TECH
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