Method for applying multi-axis robot to cell factories to prepare biological products

Abstract

The invention discloses a method for applying a multi-axis robot to cell factories to prepare biological products. The problems that in the prior art, a large amount of manual operation is needed, theconstant temperature room environment is difficult to control, thus the adverse effect on growing and amplification of cultures is caused, and the production cost is high are solved. A plurality of sets of culturing frames, arm operating openings and pipeline connecting openings cooperate with the multi-axis robot to achieve operations such as grabbing, moving, overturning and waggling of specialstructure cell factory frames to replace operating processes adopting manpower and other fixed equipment, wherein the culturing frames are sequentially arranged in a fan shape in a constant temperature room, and the arm operating openings and the pipeline connecting openings are formed in an observation window between the constant temperature room and an operation room. According to the method, the cell factories are intensively cultured and operated, operation does not need manual pushing and does not need to leave the constant temperature room, thus the culturing environment is easy to control, changing of the culture temperature is small, modular efficient production is facilitated, the product consistency is good, the pollution rate is low, and the overall operating cost can be saved.

Description

technical field [0001] The invention belongs to the technical field of biological product preparation, and specifically relates to a method that can replace manual and fixed equipment to complete the cultivation of cell matrix in a cell factory. The cultivation environment is easy to control, the temperature of the culture changes little, and it is conducive to large-scale and efficient production, and the product is consistent. Well, the contamination rate is low, and the multi-axis robot that can save the overall operating cost is applied to the method of preparing biological products in cell factories. Background technique [0002] A cell factory is a cell culture device that saves space by utilizing the maximum culture surface in a limited space; it can be used for industrial scale production such as vaccines, monoclonal antibodies or biopharmaceuticals, especially suitable for adherent cells , can also be used for suspension culture, and does not change the kinetic cond...

AI Technical Summary

Problems solved by technology

[0003] At present, the use of cell factories for the preparation of biological products generally adopts fixed equipment, that is, the cell factory is pushed onto the tumbler for liquid replacement, shaking and rotation to complete various steps of cultivation; but this traditional process There are the following disadvantages: 1. The cell factory is large in size and heavy in weight, and has high requirements on the culture environment; therefore, it is difficult to move to the flipper, which increases the workload of manual operation, and the control of the sterile environment is difficult

2. Since the cell factory needs to be pushed to the flipper for operation, the temperature environment where the cell factory is located is changed, which is not conducive to the growth and expansion of the culture

3. The cell factory flipper can only operate a group of cell factories at one time, and it needs to configure multiple devices when operating a large number of cell factories, which not only increases the production cost and the number of staff, but also restricts the production scale

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