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Method based on SVR (support vector regression) to study material basis of Gegen Qinlian decoction to improve insulin resistance

A technology of Gegen Qinlian Decoction and insulin resistance, which is applied in the field of medicine, can solve the problems of complex interrelationships, limit the confirmation and evaluation of the pharmacodynamic material basis of traditional Chinese medicines, etc., and achieve the effect of simple operation.

Active Publication Date: 2019-01-04
GUANGDONG PHARMA UNIV
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Problems solved by technology

However, due to the multi-component, multi-channel, multi-target, and multi-effect overall regulation characteristics of the traditional Chinese medicine compound system, the research on the material basis, biological effects and their relationship of the traditional Chinese medicine compound is quite complicated, which greatly limits the efficacy of traditional Chinese medicine. Confirmation and evaluation of material basis
[0004] In the prior art, there is little research on the material basis of Gegen Qinlian Decoction for treating insulin resistance, so there is an urgent need for a method that can simply, quickly and accurately obtain the material basis of Gegen Qinlian Decoction for improving insulin resistance

Method used

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  • Method based on SVR (support vector regression) to study material basis of Gegen Qinlian decoction to improve insulin resistance
  • Method based on SVR (support vector regression) to study material basis of Gegen Qinlian decoction to improve insulin resistance
  • Method based on SVR (support vector regression) to study material basis of Gegen Qinlian decoction to improve insulin resistance

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Embodiment 1

[0031] Example 1 A method for studying the material basis of Gegen Qinlian Decoction improving insulin resistance

[0032] Include the following steps:

[0033] S1. Construction of the chemical composition chromatographic database of Gegen Qinlian Decoction: Take 200g of Pueraria lobata, 75g of Coptis chinensis, 75g of Scutellaria baicalensis and 50g of licorice, first decoct the root of Pueraria lobata for 20 minutes, filter, and decoct the filter residue and the remaining three medicinal materials in water 10 times the weight Boil twice, the first time for 1 hour, the second time for 30 minutes, combine the filtrates of the two times, filter, and concentrate to obtain Gegen Qinlian Decoction with a crude drug content of 1g / ml;

[0034] Take the obtained Gegen Qinlian Decoction and put it on a macroporous resin column, and then use ethanol with a concentration of 10%, 30%, 50%, 70% and 95% to elute in sequence, collect the eluate, and obtain 5 elution sites, according to th...

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Abstract

The invention belongs to the technical field of medicine and particularly relates to a method based on SVR (support vector regression) to study material basis of Gegen Qinlian decoction to improve insulin resistance. The method comprises the steps of S1, constructing a chemical component chromatographic database of Gegen Qinlian decoction; S2, constructing a pharmacodynamic evaluation database; S3, establishing a profile-effect model based on SVR. The method herein is simple to perform, enables the material basis of Gegen Qinlian decoction to improve insulin resistance to be quickly and accurately known; solid basis is laid for the secondary development of Gegen Qinlian decoction.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for studying the material basis of Gegen Qinlian Decoction for improving insulin resistance based on SVR. Background technique [0002] Gegen Qinlian Decoction is composed of Pueraria root, Scutellaria baicalensis, Coptis chinensis and licorice. It is one of the classic ancient prescriptions. Pueraria lobata is sweet, pungent and cool, its nature is clear and light, and it enters the spleen and stomach meridian. It can not only relieve the exterior and reduce fever, but also promote the spleen and stomach to clear the yang and treat the lower body. , straight to clear heat in the interior, still thicken the stomach and intestines, strengthen yin and stop sharpness, and act as a ministerial drug; licorice and sweetness relieve the middle, harmonize various drugs, and act as an envoy drug. The four medicines are used in combination, dredging the outside and c...

Claims

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Application Information

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IPC IPC(8): G01N30/02A61K36/718A61P5/50
CPCA61K36/484A61K36/488A61K36/539A61K36/718A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P5/50G01N30/02A61K2300/00
Inventor 杨永霞汪双红
Owner GUANGDONG PHARMA UNIV
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