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4-lncRNA molecular labeling kit for liver cancer prognosis assessment

A liver cancer prognosis and kit technology, applied in liver cancer patients and tumor prognosis assessment, 4-LncRNA molecular labeling field, can solve the problem of predicting the prognosis of liver cancer patients without molecular labeling

Active Publication Date: 2021-10-15
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

[0004] So far, more than 10,000 LncRNAs have been found. Although some studies related to liver cancer have appeared, there is still no molecular signature composed of LncRNAs to help evaluate the prognosis of liver cancer patients, and the efficacy of molecular signatures that combine multiple LncRNAs Superior to single RNA molecular markers

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  • 4-lncRNA molecular labeling kit for liver cancer prognosis assessment
  • 4-lncRNA molecular labeling kit for liver cancer prognosis assessment
  • 4-lncRNA molecular labeling kit for liver cancer prognosis assessment

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Embodiment 1

[0050] The inventors used 127 samples of LNCRNA chip analysis and test groups of LNCRNA in liver cancer tissue and mobilized cancer, found to have 218 lncRNAs with a total of 1.25 times in liver cancer and cancer tissue, 85 lncRNAs Adjusted in liver cancer tissues, 133 were lowered in liver cancer tissues. Single factor Cox regression analysis of 17 lNCRNAs and prognosis of patients with via group liver cancer were prognosis, and then a set of four LNCRNA-containing molecular labels were screened by a risk fraction model. This model can calculate the risk score of each patient and divide patients into high-risk groups and low-risk groups with the median value of the overall risk score. The last KM survival analysis shows the total survival time and disease of high-risk group patients. Survival time is significantly shortened than low-risk groups. The 4-lncRNA molecular label can improve the prognostic value of the clinical stage system of liver cancer.

[0051] In order to verify ...

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Abstract

The invention discloses the application of 4‑LncRNA molecular tags in the prognosis assessment of liver cancer. The present invention evaluates the overall survival time and disease-free survival time of liver cancer patients through 4‑LncRNA molecular signatures, and finds that the overall survival time and disease-free survival time of patients in the high-risk group are significantly shorter than those in the low-risk group. In addition, 4‑LncRNA molecular signatures can improve the prognostic evaluation value of the liver cancer clinical staging system, that is, to evaluate and predict patients with the same clinical stage, and find that there are significant differences in survival time between low-risk groups and high-risk patients. It shows that the 4-LncRNA molecular tag of the present invention can be used as a detection marker for liver cancer prognosis assessment, and can provide prognosis evaluation, observation and monitoring for liver cancer patients, and be used to judge the prognosis of patients, etc., and has the advantages of rapidity, objectivity and accuracy. .

Description

Technical field [0001] The present invention relates to a biomarker in the field of manufacture of a prognostic evaluation of patients with cancer of the kit manufacturer, particularly to 4-LncRNA tag molecule assess tumor prognosis of liver cancer patients and in particular generation of tumor prognostic evaluation. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in our country, studies show that the incidence of liver cancer in the past two decades the rise in our country, its third in mortality from cancer of nine rankings up to second place. Clinical study of liver cancer in the past decade has made great progress, but the five-year survival rate of liver cancer is still very low and high recurrence rate. Thus, clinical studies alone to improve the survival rate of liver cancer patients and reduce the recurrence rate is not enough. Due to the rapid development of molecular biotechnology, and its effects in biological mac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/166C12Q2600/178
Inventor 王辉云徐睿张美殷买世娟
Owner SUN YAT SEN UNIV CANCER CENT
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