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4-LncRNA molecular tag kit for prognosis evaluation of liver cancer

A liver cancer prognosis and kit technology, which is applied in the direction of microbial determination/examination, biochemical equipment and methods, etc., can solve the problem of predicting the prognosis of liver cancer patients without molecular label evaluation, and achieve the effect of improving the value of prognosis evaluation.

Active Publication Date: 2018-11-02
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

[0004] So far, more than 10,000 LncRNAs have been found. Although some studies related to liver cancer have appeared, there is still no molecular signature composed of LncRNAs to help evaluate the prognosis of liver cancer patients, and the efficacy of molecular signatures that combine multiple LncRNAs Superior to single RNA molecular markers

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  • 4-LncRNA molecular tag kit for prognosis evaluation of liver cancer
  • 4-LncRNA molecular tag kit for prognosis evaluation of liver cancer
  • 4-LncRNA molecular tag kit for prognosis evaluation of liver cancer

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Embodiment 1

[0050] The inventors used the LncRNA chip to analyze the LncRNA expression profiles of 127 samples in the test group against liver cancer tissues and paired para-cancerous tissues, and found that there were 218 LncRNAs with a differential expression of more than 1.25 times in liver cancer and para-cancerous tissues, of which 85 LncRNAs were in Up-regulated in liver cancer tissue, 133 down-regulated in liver cancer tissue. Univariate COX regression analysis of 17 lncRNAs was significantly correlated with the prognosis of liver cancer patients in the validation group, and then a set of molecular signatures containing 4 lncRNAs was screened out through the risk score model. The model can calculate the risk score of each patient, and divide the patients into high-risk group and low-risk group based on the median value of the overall risk score. Finally, K-M survival analysis shows that the overall survival time and disease-free time of patients in the high-risk group The survival ...

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Abstract

The invention discloses an application of a 4-LncRNA molecular tag in prognosis evaluation of liver cancer. The 4-LncRNA molecular tag is used for evaluating the total survival time and the disease-free survival time of a liver cancer patient, which finds that the total survival time and the disease-free survival time of patients in a high-risk group are notably shortened as compared with patientsin a low-risk group. Besides, the prognosis evaluation value of a clinical staging system of the liver cancer can be improved by means of the 4-LncRNA molecular tag, that is, evaluation and predication of patients of the same clinical stage find that the survival time of the patients in the high-risk group is notably different from that of the patients in the low-risk group. Therefore, the 4-LncRNA molecular tag can serve as a detection marker for prognosis evaluation of liver cancer, can provide prognosis effect evaluation as well as observation and monitoring for the patients, can be used for judging the prognosis situation of the patients and has the advantages of rapidness, objectiveness, accuracy and the like.

Description

technical field [0001] The present invention relates to the field of application of biomarkers in the production of tumor patient prognosis assessment kits, in particular to the application of 4-LncRNA molecular tags in assessing the prognosis of tumor patients, especially liver cancer patients, and producing tumor prognosis assessment. Background technique [0002] Hepatocellular carcinoma (referred to as liver cancer) is one of the most common malignant tumors in my country. Studies have shown that the incidence of liver cancer has been on the rise in my country in the past two decades, and it has risen from the third place in the ranking of nine malignant tumor mortality moved up to second place. The clinical research of liver cancer has made great progress in the past ten years, but the five-year survival rate of liver cancer is still very low and the recurrence rate is high. It can be seen that clinical research alone is not enough to improve the survival rate of liver ...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/166C12Q2600/178
Inventor 王辉云徐睿张美殷买世娟
Owner SUN YAT SEN UNIV CANCER CENT
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